Gene conversion is involved in the transfer of genetic information between naturally occurring inversions of Drosophila.
Gene conversion is involved in the transfer of genetic information between naturally occurring inversions of Drosophila.
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DOI：
10.1073/pnas.91.24.11517
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发表时间：
1994-11
影响因子：
11.1
通讯作者：
J. Rozas;M. Aguadé
中科院分区：
文献类型：
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作者：
J. Rozas;M. Aguadé
确定了 34 个果蝇亚暗色等染色体菌株的核糖体蛋白 49 (rp49) 区域的 DNA 序列，它们代表两种染色体排列，OST 和 O3 + 4 基因排列，其不同之处在于两个重叠倒位。数据表明，基因转换是果蝇自然发生的倒转之间遗传信息转移的一种机制。该区域的基因转换估计的基因转移率接近反转断点，低于之前在果蝇 rosy (ry) 基因上通过实验获得的估计值。我们的数据表明基因排列 OST 和 O3 + 4 是单系的并且相当古老（分别为 0.58 和 73 万年）。
The DNA sequences of the ribosomal protein 49 (rp49) region were determined for 34 isochromosomal strains of Drosophila subobscura representing two chromosomal arrangements, the OST and the O3 + 4 gene arrangements, which differ by two overlapping inversions. The data reveal that gene conversion is a mechanism responsible for the transfer of genetic information between naturally occurring inversions of Drosophila. The estimated rate of gene transfer by gene conversion at this region, which is close to an inversion breakpoint, is lower than previous estimates obtained experimentally at the rosy (ry) gene in Drosophila melanogaster. Our data indicate that gene arrangements OST and O3 + 4 are monophyletic and rather old (0.58 and 0.73 million years old, respectively).