The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (FcεRI)
The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (FcεRI)
复制标题
DOI：
10.1016/j.imbio.2007.03.001
复制
发表时间：
2007-01-01
期刊：
影响因子：
2.8
通讯作者：
Bieber, Thomas
中科院分区：
文献类型：
--
作者：
Bieber, Thomas
在首次描述表皮朗格汉斯细胞(LC)表面的IgE以及随后在人类抗原提呈细胞(APC)上鉴定三聚体Fc epsilon RI近20年后，我们对负责这种结合的受体有了深刻的了解。Fc epsilon RI可能是特应性皮炎患者皮肤中某些APC的促炎结构，如炎症树突状表皮细胞(IDEC)，也可能是导致对其他APC耐受的重要工具，如口腔粘膜LC。通过Fc epsilon，RL APC可以通过分泌广泛的促炎细胞因子和趋化因子来启动炎症。Fc epsilon RI+DC可诱导T细胞Th2或Th1的表达。相反，色氨酸分解代谢酶吲哚-2，3-双加氧酶(IDO)以及IL-10和转化生长因子β的产生可能有助于DC的耐受特性。(C)2007年爱思唯尔股份有限公司。版权所有。
Almost 20 years after the first description of IgE on the surface of epidermal Langerhans cells (LC) and the subsequent characterization of the trimeric Fc epsilon RI on human antigen-presenting cells (APC), we have gained profound insights into the receptor responsible for this binding. Fc epsilon RI may act as a pro-inflammatory structure on some APC such as inflammatory dendritic epidermal cells (IDEC) in the skin of patients with atopic dermatitis while it can also be an important instrument in mechanisms leading to tolerance on other APC such as LC of the oral mucosa. By virtue of Fc epsilon RL APC can initiate inflammation by secretion of a wide spectrum of pro-inflammatory cytokines and chemokines. Fc epsilon RI + DC can induce either Th2 or Th1 profile in T-cells. In contrast, the production of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) as well as IL-10 and TGF beta may contribute to the tolerogenic properties of DC. (C) 2007 Elsevier GmbH. All rights reserved.