Network-specific effects of age and in-scanner subject motion: A resting-state fMRI study of 238 healthy adults
Network-specific effects of age and in-scanner subject motion: A resting-state fMRI study of 238 healthy adults
复制标题
DOI：
10.1016/j.neuroimage.2012.08.004
复制
发表时间：
2012-11-15
期刊：
影响因子：
5.7
通讯作者：
Westlye, Lars T.
中科院分区：
文献类型：
--
作者：
Mowinckel, Athanasia M.;Espeseth, Thomas;Westlye, Lars T.
认知老化伴随着大脑的一系列结构和功能差异，即使没有神经退行性疾病。功能性磁共振成像（fMRI）研究表明，与年轻人相比，老年人在执行任务时双侧激活增加，特别是在额叶区域。在休息的大脑的功能结构中也观察到了变化，这表明衰老与大脑网络组织的变化有关。然而，以前的研究主要集中在默认模式网络，而对年龄对其他静息状态网络（RSN）的影响知之甚少。本研究的目的是调查静息状态功能连接（RSFC）的年龄差异，使用从238名年龄在21-80岁的健康参与者在休息期间获得的fMRI数据。使用独立成分分析（伊卡）和双回归，结果显示，在一系列的RSN，包括任务积极的网络在额叶和顶叶区域的RSFC与年龄相关的增加。相反，观察到默认模式网络和枕叶视觉网络的年龄相关减少。此外，而年龄对各种RSN的影响被发现独立于年龄相关的灰质体积，性别和主题运动的减少，我们报告了强大的积极和广泛的影响，估计主题运动的RSFC跨RSN。这些结果支持了衰老中网络特异性效应的概念，表现为任务正性网络的紧张激活增加，支持高阶认知功能和认知控制，沿着休息期间任务负性默认模式网络和感觉视觉网络的减少。目前的研究结果也证实了最近的证据，受试者运动的强烈影响，估计功能连接措施，并强烈建议使用RSFC措施作为成像表型的研究应调整扫描仪受试者运动的个体差异。(C)2012 Elsevier Inc. All rights reserved.
Cognitive aging is accompanied by a range of structural and functional differences in the brain, even in the absence of neurodegenerative disease. Functional magnetic resonance imaging (fMRI) studies have reported increased bilateral activation during task performance in elderly participants compared to their younger counterparts, particularly in frontal regions. Alterations have also been observed in the functional architecture of the resting brain, suggesting that aging is associated with changes in the organization of the networks of the brain. However, previous studies have largely focused on the default mode network, and little is known about the effects of age on other resting state-networks (RSNs). The aim of the present study was to investigate age-differences in resting state functional connectivity (RSFC) using fMRI data obtained during rest from 238 healthy participants aged 21-80 years. Using independent component analysis (ICA) and dual-regression, the results revealed age-related increases in RSFC across a range of RSNs, including task-positive networks in frontal and parietal regions. In contrast, age-related reductions in the default mode network and occipital visual networks were observed. Furthermore, whereas the effects of age on the various RSNs were found independent of age-related decreases in gray matter volume, sex and subject motion, we report strong positive and widespread effects of estimated subject motion on the RSFC across RSNs. The results provide support for the notion of network-specific effects in aging, manifested as increased tonic activation of task-positive networks, supporting higher-order cognitive functions and cognitive control, along with reduced task-negative default mode network and sensory visual networks during rest. The present results also corroborate recent evidence of strong influence of subject motion on estimated functional connectivity measures and strongly suggest that studies using RSFC measures as imaging phenotypes should adjust for individual differences in in-scanner subject motion. (C) 2012 Elsevier Inc. All rights reserved.