A DNA-based molecular motor that can navigate a network of tracks
A DNA-based molecular motor that can navigate a network of tracks
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DOI：
10.1038/nnano.2011.253
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发表时间：
2012-03-01
影响因子：
38.3
通讯作者：
Turberfield, Andrew J.
中科院分区：
文献类型：
--
作者：
Wickham, Shelley F. J.;Bath, Jonathan;Turberfield, Andrew J.
合成分子马达可以通过 DNA 的水解 (1-4) 或杂交 (5-11) 来驱动。这种电机可以自主移动 (1-4,7,11) 和可编程 (12)，并且在线性轨道上观察到长距离传输 (13,14)。研究还表明 DNA 系统可以计算(8,15-18)。在这里，我们报告了一种基于合成 DNA 的系统，该系统集成了远程传输和信息处理。我们表明，可以使用外部添加或电机本身携带的指令对电机通过包含四种可能路线的轨道网络的路径进行编程。当使用外部控制时，我们发现 87% 的电机遵循正确的路径，而当使用内部控制时，71% 的电机遵循正确的路径。可编程运动将允许开发计算网络、可以根据货物携带的指令对货物进行分类和处理的分子系统，以及可以动态重新配置以响应不断变化的需求的装配线（19,20）。
Synthetic molecular motors can be fuelled by the hydrolysis(1-4) or hybridization(5-11) of DNA. Such motors can move autonomously(1-4,7,11) and programmably(12), and long-range transport has been observed on linear tracks(13,14). It has also been shown that DNA systems can compute(8,15-18). Here, we report a synthetic DNA-based system that integrates long-range transport and information processing. We show that the path of a motor through a network of tracks containing four possible routes can be programmed using instructions that are added externally or carried by the motor itself. When external control is used we find that 87% of the motors follow the correct path, and when internal control is used 71% of the motors follow the correct path. Programmable motion will allow the development of computing networks, molecular systems that can sort and process cargoes according to instructions that they carry, and assembly lines(19,20) that can be reconfigured dynamically in response to changing demands.