Microvascular oxygen delivery and consumption following treatment with verapamil.
Microvascular oxygen delivery and consumption following treatment with verapamil.
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维拉帕米治疗后的微血管氧输送和消耗。
DOI：
10.1152/ajpheart.00955.2004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Intaglietta,Marcos
中科院分区：
文献类型：
--
作者：
Hangai-Hoger,Nanae;Tsai,AmyG;Friesenecker,Barbara;Cabrales,Pedro;Intaglietta,Marcos
研究了清醒仓鼠窗室制剂的小动脉和小静脉中氧的微血管分布，以确定维拉帕米诱导的血管舒张期间血管平滑肌松弛对微血管壁耗氧量的贡献。盐酸维拉帕米以 0.1 mg/kg 推注，然后连续输注 0.01 mg·kg−1·min−1 引起显着的小动脉扩张，增加微血管流量和功能性毛细血管密度，并降低小动脉血管壁透壁 Po2 差。维拉帕米导致组织 Po2 从对照条件下的 25.5 ± 4.1 mmHg 增加至维拉帕米治疗期间的 32.0 ± 3.7 mmHg。微循环释放到组织的总氧保持与基线相同。如果血管舒张显着降低血管壁耗氧量，则维持组织释放相同水平的氧、增加组织 Po2 和降低壁氧浓度梯度是相容的，在该模型中，血管壁耗氧量似乎构成了重要的耗氧室。这些发现表明，维拉帕米治疗通过血管舒张增加氧供应，可以通过降低微循环的耗氧量进一步改善组织氧合。
The microvascular distribution of oxygen was studied in the arterioles and venules of the awake hamster window chamber preparation to determine the contribution of vascular smooth muscle relaxation to oxygen consumption of the microvascular wall during verapamil-induced vasodilatation. Verapamil HCl delivered in a 0.1 mg/kg bolus injection followed by a continuous infusion of 0.01 mg·kg−1·min−1caused significant arteriolar dilatation, increased microvascular flow and functional capillary density, and decreased arteriolar vessel wall transmural Po2difference. Verapamil caused tissue Po2to increase from 25.5 ± 4.1 mmHg under control condition to 32.0 ± 3.7 mmHg during verapamil treatment. Total oxygen released by the microcirculation to the tissue remained the same as at baseline. Maintenance of the same level of oxygen release to the tissue, increased tissue Po2, and decreased wall oxygen concentration gradient are compatible if vasodilatation significantly lowers vessel wall oxygen consumption, which in this model appears to constitute an important oxygen-consuming compartment. These findings show that treatment with verapamil, which increases oxygen supply through vasodilatation, may further improve tissue oxygenation by lowering oxygen consumption of the microcirculation.