Comparison of carotid baroreflex control of plasma AVP concentration in conscious and anesthetized dogs.
Comparison of carotid baroreflex control of plasma AVP concentration in conscious and anesthetized dogs.
复制标题
清醒犬和麻醉犬颈动脉压力感受反射对血浆 AVP 浓度的控制比较。
DOI：
10.1152/ajpregu.1991.261.4.r950
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Brunner,MJ
中科院分区：
文献类型：
--
作者：
Wehberg,KE;Gala,GJ;Brunner,MJ
我们比较了慢性清醒和急性麻醉犬的内源性血浆精氨酸加压素（AVP）对颈动脉窦压力感受器反射的控制。将清醒和戊巴比妥麻醉的狗的颈动脉窦双侧分离并在恒定压力下灌注。颈动脉窦压力（CSP）在200和50毫米汞柱之间变化，在25毫米汞柱的步骤在完整的清醒和麻醉狗。迷走神经切断术后重复类似的运行。监测平均动脉压（MAP）和心率（HR）。在每个CSP间隔，通过放射免疫法抽取血液用于AVP分析。MAP对CSP变化的反应在四个实验组中没有差异。麻醉和迷走神经切断术增加了HR对CSP变化的反应。在迷走神经完整的情况下，清醒犬在高CSP时AVP增加，而麻醉犬则没有。迷走神经切断术后，低CSP导致血浆AVP增加，清醒和麻醉犬之间没有差异。结果表明，AVP的释放调制的行动，颈动脉压力感受器反射作为一个完整的传出反应的正常组成部分。清醒和戊巴比妥麻醉犬的反应相似，通常由迷走神经传入反射缓冲。
We compared carotid sinus baroreflex control of endogenous plasma arginine vasopressin (AVP) in chronically prepared conscious and acutely prepared anesthetized dogs. The carotid sinuses of both conscious and pentobarbital-anesthetized dogs were isolated bilaterally and perfused at constant pressures. Carotid sinus pressure (CSP) was changed between 200 and 50 mmHg in 25-mmHg steps in intact conscious and anesthetized dogs. Similar runs were repeated after vagotomy. Mean arterial pressure (MAP) and heart rate (HR) were monitored. At each interval of CSP, blood was withdrawn for AVP analysis by radioimmunoassay. MAP responses to changes in CSP were not different in the four experimental groups. Both anesthesia and vagotomy increased the HR responses to changes in CSP. With vagi intact, AVP increased at high CSP in conscious but not in anesthetized dogs. After vagotomy, low CSP led to an increase in plasma AVP that did not differ between conscious and anesthetized dogs. The results suggest that the release of AVP is modulated by the action of the carotid baroreflex as a normal component of an integrated efferent response. The response is similar in conscious and pentobarbital-anesthetized dogs and is normally buffered by reflexes with vagal afferents.