Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry
Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry
复制标题
基于银木质素纳米颗粒触发动态氧化还原儿茶酚化学的植物启发粘合剂和坚韧水凝胶
DOI：
10.1038/s41467-019-09351-2
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发表时间：
2019-04-02
影响因子：
16.6
通讯作者：
Lu, Xiong
中科院分区：
文献类型：
--
作者：
Gan, Donglin;Xing, Wensi;Lu, Xiong
粘性水凝胶在生物医学领域得到了广泛的应用，然而，传统的粘性水凝胶往往表现出短期的溶胀，机械性能差，缺乏抗菌能力。在这里，基于银-木质素纳米颗粒（NPs）触发的动态氧化还原儿茶酚化学，开发了一种植物启发的粘合剂水凝胶。银-木质素纳米颗粒构建了动态的邻苯二酚氧化还原体系，在水凝胶网络内部创造了持久的还原-氧化环境。这种氧化还原体系，连续产生邻苯二酚基团，赋予水凝胶长期和可重复的亲水性。此外，Ag-木质素NP产生自由基并在周围环境下触发水凝胶的自凝胶化。由于水凝胶网络中存在共价和非共价相互作用，该水凝胶呈现出高韧性。由于银-木质素纳米粒的邻苯二酚基团和杀菌能力，该水凝胶还具有良好的细胞亲和性和高的抗菌活性。本研究提出了一种策略，设计坚韧和粘性水凝胶的基础上动态植物儿茶酚化学。
Adhesive hydrogels have gained popularity in biomedical applications, however, traditional adhesive hydrogels often exhibit short-term adhesiveness, poor mechanical properties and lack of antibacterial ability. Here, a plant-inspired adhesive hydrogel has been developed based on Ag-Lignin nanoparticles (NPs)triggered dynamic redox catechol chemistry. Ag-Lignin NPs construct the dynamic catechol redox system, which creates long-lasting reductive-oxidative environment inner hydrogel networks. This redox system, generating catechol groups continuously, endows the hydrogel with long-term and repeatable adhesiveness. Furthermore, Ag-Lignin NPs generate free radicals and trigger self-gelation of the hydrogel under ambient environment. This hydrogel presents high toughness for the existence of covalent and non-covalent interaction in the hydrogel networks. The hydrogel also possesses good cell affinity and high antibacterial activity due to the catechol groups and bactericidal ability of Ag-Lignin NPs. This study proposes a strategy to design tough and adhesive hydrogels based on dynamic plant catechol chemistry.