Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems.
Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems.
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DOI：
10.1109/tmi.2014.2312733
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发表时间：
2014-07
影响因子：
10.6
通讯作者：
Samei E
中科院分区：
文献类型：
--
作者：
Kiarashi N;Lo JY;Lin Y;Ikejimba LC;Ghate SV;Nolte LW;Dobbins JT 3rd;Segars WP;Samei E
乳腺X线摄影术是目前最广泛使用的检测和诊断乳腺癌的工具。然而，在乳腺组织致密的女性中，组织重叠可能会掩盖病变。数字乳腺断层合成摄影可以减少组织重叠。此外，具有对比度增强的成像可以提供关于病变的附加功能信息，诸如形态学和动力学，这进而可以改善病变识别和表征。这些成像技术的性能在很大程度上取决于乳房的结构组成，这在患者之间有很大差异。因此，成像系统和成像技术的优化应考虑患者的变异性。此外，采用造影剂的成像技术的优化应包括相对于造影剂摄取动力学的随时间变化的乳房组成。为此，我们开发了一套4-D虚拟乳房体模，它与造影剂在不同组织中传播的动力学相结合，可以逼真地模拟正常乳腺实质以及良性和恶性病变。这一发展提出了一种新的方法，在进行模拟研究，使用真正的拟人模型。为了证明所提出的4-D幻影的效用，我们提出了一个简化的例子研究，定性和定量地比较14个成像范例的性能。
Mammography is currently the most widely utilized tool for detection and diagnosis of breast cancer. However, in women with dense breast tissue, tissue overlap may obscure lesions. Digital breast tomosynthesis can reduce tissue overlap. Furthermore, imaging with contrast enhancement can provide additional functional information about lesions, such as morphology and kinetics, which in turn may improve lesion identification and characterization. The performance of these imaging techniques is strongly dependent on the structural composition of the breast, which varies significantly among patients. Therefore, imaging system and imaging technique optimization should take patient variability into consideration. Furthermore, optimization of imaging techniques that employ contrast agents should include the temporally varying breast composition with respect to the contrast agent uptake kinetics. To these ends, we have developed a suite of 4-D virtual breast phantoms, which are incorporated with the kinetics of contrast agent propagation in different tissues and can realistically model normal breast parenchyma as well as benign and malignant lesions. This development presents a new approach in performing simulation studies using truly anthropomorphic models. To demonstrate the utility of the proposed 4-D phantoms, we present a simplified example study to compare the performance of 14 imaging paradigms qualitatively and quantitatively.