Dietary Supplements/Antioxidants: Impact on Redox Status in Brain Diseases.
Dietary Supplements/Antioxidants: Impact on Redox Status in Brain Diseases.
复制标题
膳食补充剂/抗氧化剂：对脑部疾病氧化还原状态的影响。
DOI：
10.1155/2017/5048432
复制
发表时间：
2017
影响因子：
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通讯作者：
Manivasagam,Thamilarasan
中科院分区：
文献类型：
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作者：
Guillemin,GillesJ;Essa,MusthafaMohamed;Song,Byoung-Joon;Manivasagam,Thamilarasan
“智慧和优雅随年龄增长”这句话可能是对的，但不幸的是，衰老也伴随着智力下降和患痴呆症的风险增加。随着世界人口持续老龄化，阿尔茨海默病和痴呆症已成为发达国家最大的死亡原因。保持良好的大脑健康已经成为首要任务，几十年来，科学家们已经确定了一些可以减少这种认知能力下降的简单因素，包括经常锻炼和/或健康的饮食。大脑消耗了大约20%的身体氧气摄入量，这使得神经元特别容易受到氧化和自由基的损害。氧化应激，或“脑锈”，是在衰老过程中逐渐增加的有害过程之一。它会导致认知能力下降，并经常导致神经退行性疾病。中枢神经系统中活性氧（ROS）有两个主要来源：(1)线粒体产生ROS是所有细胞正常产生能量的结果；(2)激活的小胶质细胞（大脑的免疫细胞）也产生ROS，作为“武器”的一部分，它们用来破坏病原体或攻击大脑中积聚的异常蛋白质。在生理条件下，体内ROS的产生和分解代谢是平衡的。它是
While the saying “wisdom and grace come with age” may be true, unfortunately, ageing also comes with a package of decreased mental abilities and an increased risk of dementia. As the world’s population continues to age, Alzheimer’s disease and dementia have become the largest causes of death in developed countries. Maintaining good brain health has become a major priority, and, over several decades, scientists have identified some simple factors that can reduce this cognitive decline, including regular exercise and/or a healthy diet.The brain uses roughly 20% of all the body oxygen intake making neurons particularly susceptible to oxidative and free radical damage. Oxidative stress, or “brain rust,” is one of the deleterious processes that progressively increases during the ageing process. It leads to cognitive decline and often to neurodegenerative diseases. There are two main sources for reactive oxygen species (ROS) within the central nervous system:(1) mitochondria are producing ROS as a result of the normal production of energy in all cells and (2) activated microglia (the immune cells of the brain) are also producing ROS as part of the “weaponry” they use to destroy pathogens or attack abnormal proteins accumulating in the brain. Under physiological conditions, there is an equilibrium between ROS production and catabolism in the body. It is