Auditory and Visual Modulation of Temporal Lobe Neurons in Voice-Sensitive and Association Cortices
Auditory and Visual Modulation of Temporal Lobe Neurons in Voice-Sensitive and Association Cortices
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DOI：
10.1523/jneurosci.2805-13.2014
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发表时间：
2014-02-12
影响因子：
5.3
通讯作者：
Petkov, Christopher I.
中科院分区：
文献类型：
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作者：
Perrodin, Catherine;Kayser, Christoph;Petkov, Christopher I.
同种个体之间的有效交互可能取决于接收者形成通信信号的连贯多感官表示，例如合并语音和面部内容。神经影像学研究已经确定了面部或声音敏感区域（Belin et al., 2000; Petkov et al., 2008; Tsao et al., 2008），其中一些已被提议作为面部和声音整合的候选区域（von Kriegstein et al., 2005）。然而，目前尚不清楚多感觉影响如何在声音或面部敏感区域的神经元水平上发生，特别是与颞关联皮层中经典定义的多感觉区域相比（Stein和Stanford，2008）。在这里，我们描述了恒河猴前颞上平面（STP）右半球声音敏感区域的听觉（声音）和视觉（面部）对神经元反应的影响。将这些结果与邻近的颞上沟 (STS) 的结果进行比较。在 STP 中，我们的结果显示了对几种声音特征的听觉敏感性，这在 STS 单元中并不明显。我们还新发现了 STP 中功能独特的神经元亚群，该亚群似乎携带该区域对语音识别相关特征的敏感性。视听互动在 STP 和 STS 中都很突出。然而，与 STP 神经元相比，视觉影响以更大的特异性调节 STS 神经元的反应，并且更经常与一致的语音-面部刺激配对相关。总之，这些结果揭示了灵长类动物中支持声音敏感的功能磁共振成像活动模式的神经元过程，生成了用于视觉模态测试的假设，并阐明了声音敏感区域在单感觉和多感觉处理层次中的位置。
Effective interactions between conspecific individuals can depend upon the receiver forming a coherent multisensory representation of communication signals, such as merging voice and face content. Neuroimaging studies have identified face-or voice-sensitive areas (Belin et al., 2000; Petkov et al., 2008; Tsao et al., 2008), some of which have been proposed as candidate regions for face and voice integration (von Kriegstein et al., 2005). However, it was unclear how multisensory influences occur at the neuronal level within voice-or face-sensitive regions, especially compared with classically defined multisensory regions in temporal association cortex (Stein and Stanford, 2008). Here, we characterize auditory (voice) and visual (face) influences on neuronal responses in a right-hemisphere voice-sensitive region in the anterior supratemporal plane (STP) of Rhesus macaques. These results were compared with those in the neighboring superior temporal sulcus (STS). Within the STP, our results show auditory sensitivity to several vocal features, which was not evident in STS units. We also newly identify a functionally distinct neuronal subpopulation in the STP that appears to carry the area's sensitivity to voice identity related features. Audiovisual interactions were prominent in both the STP and STS. However, visual influences modulated the responses of STS neurons with greater specificity and were more often associated with congruent voice-face stimulus pairings than STP neurons. Together, the results reveal the neuronal processes subserving voice-sensitive fMRI activity patterns in primates, generate hypotheses for testing in the visual modality, and clarify the position of voice-sensitive areas within the unisensory and multisensory processing hierarchies.