Reperfusion Strategies for Acute Ischemic Stroke
Reperfusion Strategies for Acute Ischemic Stroke
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DOI：
10.1177/0003319711414269
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发表时间：
2012-05-01
期刊：
影响因子：
2.8
通讯作者：
Mukherjee, Debabrata
中科院分区：
文献类型：
--
作者：
Falluji, Nezar;Abou-Chebl, Alex;Mukherjee, Debabrata
中风仍然是世界范围内发病率和死亡率的主要原因。尽管采取了预防措施，但仍需要有效的管理策略来降低与这种毁灭性疾病相关的发病率和死亡率。虽然出血性卒中的管理主要限于支持性治疗，但缺血性卒中的再灌注策略已经开发并继续发展。从概念上讲，缺血性卒中的病理生理学与急性心肌梗死相似，治疗目标也相似（即快速恢复正常血流以减少永久性损伤）。因此，急性缺血性卒中的治疗包括静脉内（IV）溶栓，这是目前唯一获得食品和药物管理局（FDA）批准的策略，这并不奇怪。此外，还有无数新兴的血管内介入技术。我们回顾了目前的文献，并讨论了急性缺血性卒中血管内治疗的一些技术问题。
Stroke remains a major cause of morbidity and mortality worldwide. Despite preventive measures, effective management strategies are needed to reduce the morbidity and mortality associated with this devastating condition. While the management of hemorrhagic stroke is mostly limited to supportive care, reperfusion strategies in ischemic stroke have been developed and continue to evolve. Conceptually, the pathophysiology of ischemic stroke is similar to that of acute myocardial infarction and the objective of management is similar (ie, to rapidly restore normal flow to reduce permanent damage). It is, therefore, not surprising that the management of acute ischemic stroke includes intravenous (IV) thrombolysis, the only Food and Drug Administration (FDA)-approved strategy at this point. In addition, there are a myriad of emerging endovascular interventional techniques. We review the current literature and discuss some of the technical aspects of endovascular therapy in the setting of acute ischemic stroke.