Breast-feeding and risk for childhood obesity
Breast-feeding and risk for childhood obesity
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DOI：
10.2337/dc06-0974
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发表时间：
2006-10-01
期刊：
影响因子：
16.2
通讯作者：
Gillman, Matthew W.
中科院分区：
文献类型：
--
作者：
Mayer-Davis, Elizabeth J.;Rifas-Shiman, Sheryl L.;Gillman, Matthew W.
目的-我们试图评估是否产妇糖尿病或体重状况减弱了以前报道的有益影响母乳喂养对childhood obesity.Research设计和方法-成长起来的今天的研究（GUTS）的参与者是后代的妇女谁参加了护士的健康研究，如果。本研究包括15 253名女孩和男孩（1996年为9-14岁）。通过母亲自我报告获得母亲糖尿病和体重状况以及婴儿喂养情况。我们将母亲超重定义为BMI >= 25 kg/m2。儿童肥胖，从自我报告的身高和体重，是基于疾病控制和预防中心的定义为正常，超重的风险，或超重。母亲状态分类为非糖尿病/正常体重、非糖尿病/超重或糖尿病。Logistic回归模型使用广义估计方程来解释nonindependence between siblings.RESULTS -对于所有受试者相结合，母乳喂养与减少超重（与正常体重相比）在儿童期。经年龄、性别和坦纳分期调整后，纯母乳喂养与纯配方奶粉喂养相比，优势比（OR）为0.66（95%CI 0.53-0.82）。结果没有根据母亲的状态而不同（非糖尿病/正常体重OR 0.73 [95% CI 0.49-1.09];非糖尿病/超重0.75 [0.57-0.99];糖尿病0.62 [0.24-1.60]）。进一步调整潜在的混杂因素减弱了结果，但结果仍然是一致的产妇状态的分层（P值为0.50）。结论-母乳喂养与儿童肥胖呈负相关，无论母亲的糖尿病状态或体重状况。这些数据为所有母亲母乳喂养婴儿以减少儿童超重的风险提供了支持。
OBJECTIVE - We sought to evaluate whether maternal diabetes or weight status attenuates a previously reported beneficial effect of breast-feeding on childhood obesity.RESEARCH DESIGN AND METHODS - Growing Up Today Study (GUTS) participants were offspring of women who participated in the Nurses' Health Study if. In the present study, 15,253 girls and boys (aged 9-14 years in 1996) were included. Maternal diabetes and weight status and infant feeding were obtained by maternal self-report. We defined maternal overweight as BMI >= 25 kg/m(2). Childhood obesity, from self-reported height and weight, was based on the Centers for Disease Control and Prevention definitions as normal, at risk for overweight, or overweight. Maternal status categories were nondiabetes/normal weight, nondiabetes/overweight, or diabetes. Logistic regression models used generalized estimating equations to account for nonindependence between siblings.RESULTS - For all subjects combined, breast-feeding was associated with reduced overweight (compared with normal weight) in childhood. Compared with exclusive use of formula, the odds ratio (OR) for exclusive breast-feeding was 0.66 (95% CI 0.53-0.82), adjusted for age, sex, and Tanner stage. Results did not differ according to maternal status (nondiabetes/normal weight OR 0.73 [95% CI 0.49-1.09]; nondiabetes/overweight 0.75 [0.57-0.99]; and diabetes 0.62 [0.24-1.60]). Further adjustment for potential confounders attenuated results, but results remained consistent across strata of maternal status (P value for interaction was 0.50).CONCLUSIONS- Breast-feeding was inversely associated with childhood obesity regardless of maternal diabetes status or weight status. These data provide support for all mothers to breast-feed their infants to reduce the risk for childhood overweight.