Ratiometric Electrochemical Sensors Associated with Self-Cleaning Electrodes for Simultaneous Detection of Adrenaline, Serotonin, and Tryptophan
Ratiometric Electrochemical Sensors Associated with Self-Cleaning Electrodes for Simultaneous Detection of Adrenaline, Serotonin, and Tryptophan
复制标题
与自清洁电极相关的比率电化学传感器可同时检测肾上腺素、血清素和色氨酸
DOI：
10.1021/acsami.8b22572
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发表时间：
2019
影响因子：
9.5
通讯作者：
Li Yingchun
中科院分区：
文献类型：
--
作者：
Zhang Junjie;Wang Dongyang;Li Yingchun
电化学传感器长期以来存在吸附不专一、抗干扰性差、受到内外干扰等问题。为了应对这些挑战，我们开发了一种简便的电化学方法，它将比率计量法与自清洁电极相结合。在新型传感系统中，通过聚二甲基硅氧烷(PDMS)前驱体蒸发在炭化的ZIF-67@ZIF-8(CZIF)表面形成疏水层，实现了电极的自清洁。在比色法方面，值得一提的是，在电解液中直接加入内标物(亚甲基蓝)进行测定，与传统的比色法相比操作更加简便灵活。充分探索了自清洁电极的传感性能和新建立的比例计算法，结果表明，PDMS@cZIF纳米复合材料具有良好的电催化能力、超疏水性能和稳定性。此外，比率测量策略显著提高了电化学传感的稳健性和重复性。在最佳实验条件下，对ADR、5-羟色胺和色氨酸进行了同时检测，线性范围宽，检出限低。最后，将该比例式电化学传感器成功地应用于生物样品中三种目标分子的监测。
Electrochemical sensors have long suffered from issues such as nonspecific adsorption, poor anti-interference ability, and internal and external disturbances. To address these challenges, we developed a facile electrochemical method, which integrated a ratiometric strategy with self-cleaning electrodes. In the novel sensing system, the self-cleaning electrode was realized via forming a hydrophobic layer on carbonized ZIF-67@ZIF-8 (cZIF) by polydimethylsiloxane (PDMS) precursor vaporization. As for ratiometry, it is worth to mention that the measurements were conducted by adding an interior reference (methylene blue) directly into electrolyte solution, which is more facile and flexible to operate compared with conventional ones. Sensing performance of the self-cleaning electrode as well as the newly established ratiometric strategy was explored fully, and it turned out that PDMS@cZIF nanocomposites provided decent electrocatalytic ability, superhydrophobic property, and stability. Furthermore, the ratiometric strategy significantly elevated the robustness and reproducibility of electrochemical sensing. Simultaneous detection of Adr, 5-HT, and Trp was performed under the optimum experimental conditions with wide linear ranges and low detection limits. Finally, the original ratiometric electrochemical sensor was successfully applied for monitoring the three target molecules in biological samples.