Adsorption of plasma proteins in solution to uncharged, hydrophobic polymer surfaces.
Adsorption of plasma proteins in solution to uncharged, hydrophobic polymer surfaces.
复制标题
DOI：
10.1002/jbm.820030114
复制
发表时间：
1969-03-01
期刊：
影响因子：
--
通讯作者：
Lyman, D J
中科院分区：
文献类型：
--
作者：
Brash, J L;Lyman, D J
红外内反射光谱已用于研究某些血浆蛋白在各种疏水性聚合物表面上的吸附。所研究的系统的行为几乎相同。在静态条件下，蛋白质似乎以单分子层的形式从浓度在几毫克％到正常血浆水平之间变化的溶液中快速吸附。这些单层被推断为紧密堆积的阵列，其中蛋白质分子似乎保留了其天然的球状形式。这些结果对表面诱导凝固机制具有重要意义。
Infraref internal reflection spectroscopy has been used to study the adsorption of certain plasma proteins on a variety of hydrophobic polymer surfaces. The behavior of the systems studied was almost identical. Under Static conditions the proteins appear to be rapidly adsorbed as monomolecular layers from solutions varying in concentration between a few mg‐% and normal plasma levels. These monolayers are deduced to be closely packed arrays in which the protein molecules appear to retain their native globular form. The bearing of these results on the mechanism of surface‐induced coagulation is significant.