Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
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DOI：
10.3390/cancers6021138
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发表时间：
2014-05-14
期刊：
影响因子：
5.2
通讯作者：
Seng S
中科院分区：
文献类型：
--
作者：
Xue J;Yang S;Seng S
烟草使用是全世界的一个重大公共卫生问题。与烟草有关的癌症每年造成数百万人死亡。虽然几种烟草制剂在肿瘤的发展中起作用，但4-（甲基亚硝胺基）-1-（3-吡啶基）-1-丁酮（NNK）和N '-亚硝基去甲烟碱（NNN）的强效作用是独特的。代谢激活的NNK和NNN通过形成DNA加合物诱导癌基因和肿瘤抑制基因的有害突变，这可以被认为是肿瘤的起始。同时，NNK和NNN与烟碱乙酰胆碱受体的结合通过增强和解除对细胞增殖、存活、迁移和侵袭的调节来促进肿瘤生长，从而为肿瘤生长创造微环境。NNK和NNN的这两个独特方面协同诱导烟草暴露个体的癌症。本文将讨论各种类型的烟草制品和烟草相关的癌症，以及亚硝胺，如NNK和NNN，诱发癌症的分子机制。
Tobacco use is a major public health problem worldwide. Tobacco-related cancers cause millions of deaths annually. Although several tobacco agents play a role in the development of tumors, the potent effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) are unique. Metabolically activated NNK and NNN induce deleterious mutations in oncogenes and tumor suppression genes by forming DNA adducts, which could be considered as tumor initiation. Meanwhile, the binding of NNK and NNN to the nicotinic acetylcholine receptor promotes tumor growth by enhancing and deregulating cell proliferation, survival, migration, and invasion, thereby creating a microenvironment for tumor growth. These two unique aspects of NNK and NNN synergistically induce cancers in tobacco-exposed individuals. This review will discuss various types of tobacco products and tobacco-related cancers, as well as the molecular mechanisms by which nitrosamines, such as NNK and NNN, induce cancer.
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影响因子：
168.9
作者：
Danaei, G;Vander Hoorn, S;Ezzati, M
通讯作者：
Ezzati, M
影响因子：
7.4
作者：
BILODEAU, JF;WANG, MY;CASTONGUAY, A
通讯作者：
CASTONGUAY, A
DOI：
10.3390/v5020708
发表时间：
2013-02-12
期刊：
Viruses
影响因子：
--
作者：
De Marco F
通讯作者：
De Marco F
DOI：
10.1073/pnas.0509313103
发表时间：
2006-04-18
影响因子：
11.1
作者：
Dasgupta, P;Kinkade, R;Chellappan, S
通讯作者：
Chellappan, S
影响因子：
3.6
作者：
Arredondo, Juan;Chernyavsky, Alex I.;Grando, Sergei A.
通讯作者：
Grando, Sergei A.