Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats
Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats
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DOI：
10.1016/s0006-8993(97)00012-7
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发表时间：
1997-04-18
期刊：
影响因子：
2.9
通讯作者：
Woodward, DJ
中科院分区：
文献类型：
--
作者：
Chang, JY;Zhang, LL;Woodward, DJ
在9只雄性Sprague道利大鼠上进行了前额叶皮层（NAC）和丘脑核（NAc）神经元反应的慢性多通道单单位记录，以确定海洛因自我给药过程中神经元活动的模式。多达32个神经元同时记录在这两个脑区，而大鼠杠杆按下连续强化时间表静脉输注海洛因（30 μ g/kg/输液）。在每次自我注射海洛因之前和之后观察到的神经元反应的多样性可以根据以下类别进行分类：（1）在按压杠杆之前立即增加或（2）减少其活性的神经元;（3）在注射海洛因之后增加或（4）减少其活性的神经元;（5）在注射海洛因前或注射海洛因后，神经元的活动均未发生变化。大多数神经元（PEC中69%，NAc中65%）都属于最后一类没有变化的神经元，这表明在这个特定任务中，选定的部分变得活跃。在一般情况下，NAc神经元显示更多的海洛因后反应比PFC神经元，而神经元的比例显示前的杠杆压力是相似的，在mPFC和NAc。PFC和NAc神经元的反应在海洛因自我管理的初步描述表明，中皮质边缘系统的神经元回路参与海洛因自我管理。该回路似乎通过激活不同的神经元子集来促进药物寻求行为（杠杆按压前阶段性神经元反应）以及海洛因输注本身的作用（输注后阶段性神经元反应）。
Chronic multi-channel single unit recordings of neuronal responses in prefrontal cortex (NAC) and nucleus accumbens (NAc) were made in 9 male Sprague Dawley rats to determine patterns of neuronal activity during heroin self-administration. Up to 32 neurons were recorded simultaneously in these two brain regions while rats lever pressed on a continuous reinforcement schedule for intravenous infusion of heroin (30 mu g/kg/infusion). The variety of neuronal responses observed before and after each self-administered heroin infusion can be classified according to the following categories: (1) neurons that increased or (2) decreased their activity immediately before the lever press; (3) neurons that increased or (4) decreased their activity after the heroin infusion; and, (5) neurons that did not alter their activity either before or after the lever press for heroin infusion. The majority (69% in the PEC and 65% in the NAc) of neurons sampled fell into this last category of no change, indicating that a selected fraction becomes active during this specific task. In general, NAc neurons displayed more post-heroin responses than PFC neurons while the proportion of neurons showing responses before the lever press was similar in the mPFC and the NAc. This initial description of the responses of PFC and NAc neurons during heroin self-administration suggests that the neuronal circuit of the mesocorticolimbic system is involved in heroin self-administration. This circuit appears to contribute both to the initiation of drug-seeking behavior (pre-lever press phasic neuronal responses), as well as the action of heroin infusion itself (post infusion phasic neuronal responses) by activation of different subsets of neurons.