Mussel-designed protective coatings for compliant substrates.

Mussel-designed protective coatings for compliant substrates.
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贻贝设计的防护涂层用于合规的底物。

DOI:
10.1177/154405910808700808
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发表时间:
2008-08
影响因子:
7.6
通讯作者:
Waite, J. H.
Waite, J. H.
中科院分区:
医学1区
文献类型:
--
作者:
Holten-Andersen, N.;Waite, J. H.

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海洋贻贝的腹节作为一种强大而多样的水下粘附性范例而引起了人们的注意。紫贻贝足部蛋白-1(Mytilus edulis Foot Protein-1,mefp-1)作为第一个被提纯的含3,4-二羟基苯丙氨酸(DOPA)的生物前体,其分子结构、物理性质以及在表面的吸附等方面得到了广泛的研究。虽然mefp-1无疑有助于字节骨的耐久性,但它并不直接参与粘连。相反,它提供了一层坚固的涂层,比它所覆盖的筋膜胶原层坚硬4-5倍。柔顺组织和材料的保护性涂层对技术非常有吸引力,尽管传统观点认为,只有以硬度和硬度为代价才能增加涂层的延伸性。角质层是唯一已知的高顺应性和硬度共存而没有相互损害的涂层;因此,mefp-1在调节这两个参数方面的作用值得进一步研究。
The byssus of marine mussels has attracted attention as a paradigm of strong and versatile underwater adhesion. As the first of the 3,4-dihydroxyphenylalanine (Dopa)-containing byssal precursors to be purified, Mytilus edulis foot protein-1 (mefp-1) has been much investigated with respect to its molecular structure, physical properties, and adsorption to surfaces. Although mefp-1 undoubtedly contributes to the durability of byssus, it is not directly involved in adhesion. Rather, it provides a robust coating that is 4-5 times stiffer and harder than the byssal collagens that it covers. Protective coatings for compliant tissues and materials are highly appealing to technology, notwithstanding the conventional wisdom that coating extensibility can be increased only at the expense of hardness and stiffness. The byssal cuticle is the only known coating in which high compliance and hardness co-exist without mutual detriment; thus, the role of mefp-1 in accommodating both parameters deserves further study.
DOI: 10.1021/la970881w
发表时间: 1998-03-03
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