Pesticides and lung cancer risk in the agricultural health study cohort
Pesticides and lung cancer risk in the agricultural health study cohort
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DOI：
10.1093/aje/kwh290
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发表时间：
2004-11-01
影响因子：
5
通讯作者：
Blair, A
中科院分区：
文献类型：
--
作者：
Alavanja, MCR;Dosemeci, M;Blair, A
在农业健康研究中，作者研究了50种广泛使用的农用杀虫剂与肺癌发病率的关系，这是一项前瞻性队列研究，涉及57284名农药施用者和32333名没有肺癌病史的农民施药者的配偶。自填问卷是在入学时(1993-1997年)完成的。癌症发病率是通过基于人群的癌症登记来确定的，从登记到2001年12月31日。总体上观察到肺癌标准化发病率为0.44(95%可信区间：0.39，0.49)，这在很大程度上是由于吸烟流行率较低。两种广泛使用的除草剂异丙甲草胺和二甲戊灵(对于低暴露组和四种较高暴露类别：优势比(OR)=1.0、1.6、1.2、5.0；P(趋势)=0.0002；OR=1.0、1.6、2.1、4.4；P(趋势)=0.003)和两种广泛使用的杀虫剂毒死蜱和二氮磷(OR=1.0、1.1、1.7、1.9；P(趋势)=0.03；OR分别为1.0、1.6、2.7、3.7；p(趋势)=0.04，显示了肺癌暴露反应的某些证据。这些过度行为无法用先前确定的肺癌风险因素来解释。这组人群中的使用水平远远高于普通人群通常经历的水平。目前还不能评估直接接触杀虫剂的配偶之间的过度风险。
The authors examined the relation between 50 widely used agricultural pesticides and lung cancer incidence in the Agricultural Health Study, a prospective cohort study of 57,284 pesticide applicators and 32,333 spouses of farmer applicators with no prior history of lung cancer. Self-administered questionnaires were completed at enrollment (1993-1997). Cancer incidence was determined through population-based cancer registries from enrollment through December 31, 2001. A lung cancer standardized incidence ratio of 0.44 (95% confidence interval: 0.39, 0.49) was observed overall, due in large part to a low cigarette smoking prevalence. Two widely used herbicides, metolachlor and pendimethalin (for low-exposed groups to four higher exposure categories: odds ratio (OR) = 1.0, 1.6, 1.2, 5.0; p(trend) = 0.0002; and OR = 1.0, 1.6, 2.1, 4.4; p(trend) = 0.003, respectively), and two widely used insecticides, chlorpyrifos and diazinon (OR = 1.0, 1.1, 1.7, 1.9; p(trend) = 0.03; and OR = 1.0, 1.6, 2.7, 3.7; p(trend) = 0.04, respectively), showed some evidence of exposure response for lung cancer. These excesses could not be explained by previously identified lung cancer risk factors. The usage levels in this cohort are considerably higher than those typically experienced by the general population. An excess risk among spouses directly exposed to pesticides could not be evaluated at this time.