Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia
Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia
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DOI：
10.1902/jop.1999.70.11.1313
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发表时间：
1999-11-01
影响因子：
4.3
通讯作者：
Iacopino, AM
中科院分区：
文献类型：
--
作者：
Cutler, CW;Machen, RL;Iacopino, AM
背景资料：我们以前在糖尿病（DB）大鼠中的研究表明，高脂血症可能导致牙周炎（AP）的细胞和局部细胞因子反应失调。本研究的目的是确定糖尿病是否具有类似的调节失调的影响牙龈反应AP在human.Methods：外周血，以及牙龈组织（GT）和龈沟液（GCF），是从总共35例谁被分为以下几组的基础上糖尿病（2型）控制和成人牙周炎（AP）的存在或不存在的水平：第1组，全身和牙周健康（n = 6）;第2组，全身健康伴成人牙周炎（n = 7）;第3组，糖尿病控制良好且牙周健康（n = 6）;第4组，糖尿病控制良好且牙周炎（n = 5）;第5组，糖尿病控制不良且牙周健康（n = 5）;第6组，糖尿病控制不良伴成人牙周炎组（n = 6）。所有受试者都进行了全面的牙周检查，包括探测深度（PD），临床附着水平（CAL），牙龈指数（GI），菌斑指数（PI）和垂直咬翼片。血液研究包括糖化血红蛋白（HbA（1c））、甘油三酯（TG）、胆固醇（CHL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）水平。白细胞介素-1 β的水平采用酶联免疫吸附试验（ELISA）分析各组患者GCF和GT中的IL-1 β、IL-6和GT中的血小板衍生生长因子AB（PDGF-AB）。我们的结果表明，控制不良和控制良好的糖尿病患者除PI外的所有临床指标均显着升高，与全身健康的患者相比，但仅在未发生AP的受试者中（Tukey多重比较，P
Background: Our previous studies in diabetic (DB) rats suggest that hyperlipidemia may cause a dysregulation of the cellular and local cytokine response to periodontitis (AP). The objective of the present study was to determine if diabetes has a similar dysregulatory effect on the gingival response to AP in humans.Methods: Peripheral blood, as well as gingival tissue (GT) and gingival crevicular fluid (GCF), was obtained from a total of 35 patients who were categorized into the following groups based on level of diabetic (type 2) control and presence or absence of adult periodontitis (AP): group 1, systemically and periodontally healthy (n = 6); group 2, systemically healthy with adult periodontitis (n = 7); group 3, well-controlled diabetes and periodontally healthy (n = 6); group 4, well-controlled diabetes with adult periodontitis (n = 5); group 5, poorly controlled diabetes and periodontally healthy (n = 5); group 6, poorly controlled diabetes and adult periodontitis (n = 6). All subjects were given a thorough periodontal examination, including probing depths (PD), clinical attachment levels (CAL), gingival index (GI), plaque index (PI), and vertical bitewing radiographs. Blood studies included levels of glycated hemoglobin (HbA(1c)), triglycerides (TG), cholesterol (CHL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). The levels of interleukin-1 beta (IL-1 beta) in GCF and GT, interleukin-6 (IL-6), and platelet-derived growth factor AB (PDGF-AB) in GT from patients in each experimental group were analyzed by enzyme-linked immunosorbent assay (ELISA).Results: Our results indicate that all clinical indices except PI were significantly elevated in the poorly controlled and well-controlled diabetics, compared to systemically healthy patients, but only in the subjects without preexisiting AP (Tukey's multiple comparisons, P