NeoPeptide: an immunoinformatic database of T-cell-defined neoantigens
NeoPeptide: an immunoinformatic database of T-cell-defined neoantigens
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NeoPeptide：T 细胞定义的新抗原的免疫信息学数据库
DOI：
10.1093/database/baz128
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发表时间：
2019-12-09
影响因子：
5.8
通讯作者：
Liu, Jian
中科院分区：
文献类型：
--
作者：
Zhou, Wei-Jun;Qu, Zhi;Liu, Jian
治疗性疫苗是一种很有前途的抗癌免疫治疗方式。抗原的发现和验证是开发有效抗癌疫苗的关键。新抗原产生于个体癌症的体细胞突变，由于其免疫原性和在正常组织中缺乏表达，被认为是理想的癌症疫苗靶点。然而，只有少数数据库支持方便地获取这些用于疫苗的新抗原。为了解决这一问题，我们开发了一个名为NeoPeptide的网络数据库，该数据库包含了来自已发表文献和其他免疫学资源的新抗原的大多数重要特征（如突变位点、亚基序列、主要组织相容性复合体限制）。NeoPeptide还提供了进一步表征这些新抗原新特征的资源链接。NeoPeptide将定期更新新发现和发表的新抗原。我们的工作将帮助研究人员识别不同癌症中的新抗原，并加快寻找合适的癌症候选疫苗。
Abstract Therapeutic vaccines represent a promising immunotherapeutic modality against cancer. Discovery and validation of antigens is the key to develop effective anti-cancer vaccines. Neoantigens, arising from somatic mutations in individual cancers, are considered as ideal cancer vaccine targets because of their immunogenicity and lack of expression in normal tissues. However, only few databases support convenient access to these neoantigens for use in vaccines. To address this gap, we developed a web-accessible database, called NeoPeptide, which contains most of the important characteristics of neoantigens (such as mutation site, subunit sequence, major histocompatibility complex restriction) derived from published literature and other immunological resources. NeoPeptide also provides links to resources for further characterization of the novel features of these neoantigens. NeoPeptide will be regularly updated with newly identified and published neoantigens. Our work will help researchers in identifying neoantigens in different cancers and hasten the search for appropriate cancer vaccine candidates.