Novel materials for bioanalytical and biomedical applications: Environmental response and binding/release capabilities of amphiphilic hydrogels with shape‐persistent dendritic junctions
Novel materials for bioanalytical and biomedical applications: Environmental response and binding/release capabilities of amphiphilic hydrogels with shape‐persistent dendritic junctions
复制标题
用于生物分析和生物医学应用的新型材料：具有形状持久树突连接的两亲性水凝胶的环境响应和结合/释放能力
DOI：
10.1002/pola.20898
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
I. Gitsov
中科院分区：
文献类型：
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作者：
Chao Zhu;C. Hard;Caiping Lin;I. Gitsov
由亲水性聚乙二醇段和疏水性树突状连接[聚苯醚]构成的水凝胶系列的结合和释放能力在水介质中进行了评估。两亲网络的环境响应也在三种pH值的水中进行了测试：1.5、7.0和10.1。在酸性条件下观察到最高的溶胀率，根据交联密度和树突生成的不同，在3.7到6.5之间变化。嵌入指示剂的凝胶样品在3-6 s内随周围介质pH值的变化反应，颜色切换清晰。用模型阴离子和阳离子指示剂及染色剂进行的实验表明，水凝胶具有基本的内部结构。凝胶结合能力取决于底物的水溶性和结合的树突碎片的大小。模型释放研究在37°C和ph 1.5、7.0和10.1下进行。观察到的现象可以用网络和模型化合物的结构和电荷随着水介质pH值的变化而发生的变化来解释。©2005 Wiley期刊公司[J] .化学工程学报，2005,25 (3):557 - 557
The binding and release capabilities of a hydrogel series, constructed of hydrophilic poly(ethylene glycol) segments and hydrophobic dendritic junctions [poly (benzyl ether)s], are evaluated in aqueous media. The environmental response of the amphiphilic networks is also tested in water at three pH values: 1.5, 7.0, and 10.1. The highest swelling ratio is observed under acidic conditions and varies between 3.7 and 6.5, depending on the crosslinking density and dendrimer generation. Gel specimens with embedded indicators react within 3–6 s with a clear color switch to the change in the pH of the surrounding medium. The experiments with model anionic and cationic indicators and stains show that the hydrogels have basic interiors. The gel binding capabilities depend on the water solubility of the substrate and on the size of the incorporated dendritic fragments. Model release studies have been performed at 37 °C and pHs 1.5, 7.0, and 10.1. The observed phenomena are explained by the transformations in the structure and charge that both the networks and the model compounds undergo with the changes in the pH of the aqueous medium. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 4017–4029, 2005