METABOLISM OF BISPHENOL A IN RAT
METABOLISM OF BISPHENOL A IN RAT
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DOI：
10.1016/s0041-008x(66)80001-7
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发表时间：
1966-01-01
影响因子：
3.8
通讯作者：
SULLIVAN, LJ
中科院分区：
文献类型：
--
作者：
KNAAK, JB;SULLIVAN, LJ
对大鼠口服双酚A- cl4的代谢命运进行了研究。在8天的时间里，28%的C14随尿液排出，56%随粪便排出。呼吸CO2中未检测到C14O2, 8 d后胴体中未检测到Cl4残留。通过气相色谱法和红外光谱法得到了相应的信息。用离子交换和气相色谱法检测尿液中的代谢产物。结果表明，双酚A主要以葡萄糖醛酸盐的形式排出体外。尿液中只有不到1%的物质是游离双酚a，没有证据表明存在无形的硫酸盐。提取粪便中的代谢物，用气相色谱法检测。该物质中约35%被鉴定为游离双酚A，而另外35%被鉴定为双酚A的羟基化产物，其余30%无法进行色谱分析，可能以共轭物的形式存在。将这些结果与文献中对其他二酚的研究进行比较，结果一致认为这些化合物以葡萄糖醛酸酯的形式排出体外，而不是以硫酸盐的形式排出体外。
A study has been made of the metabolic fate of an orally administered dose of bisphenol A-Cl4 in the rat. Over an 8-day period 28% of the C14 was excreted in the urine and 56% in the feces. No C14O2 could be detected in respiratory CO2, and at the end of 8 days no Cl4 residues could be detected in the carcass. Corollary information was obtained by gas chromatography and infrared spectro-scopy. The metabolic products appearing in the urine were examined by ion exchange and gas chromatography. The results show that bisphenol A is primarily excreted as the glucuronide. Less than 1% of the material present in urine was free bisphenol A. No evidence was found for the existence of ethereal sulfates. The metabolites appearing in the feces were extracted and examined by gas chromatography. Some 35% of this material was identified as free bisphenol A, while an additional 35% was identified as a hydroxylated product of bisphenol A. The remaining 30% could not be chromatographed and was probably present as a conjugate. Comparison of these results with literature studies on other diphenols are in agreement that these compounds are excreted as glucuronides, not as ethereal sulfates.