I. The effect of p-nonylphenol, an environmental toxicant with oestrogenic properties, on fertility potential in adult male rats
I. The effect of p-nonylphenol, an environmental toxicant with oestrogenic properties, on fertility potential in adult male rats
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DOI：
10.1046/j.1439-0272.1999.00245.x
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发表时间：
1999-03-01
期刊：
影响因子：
2.4
通讯作者：
van der Horst, G
中科院分区：
文献类型：
--
作者：
de Jager, C;Bornman, MS;van der Horst, G
不孕症是一个可悲的现实，现在很明显，在过去30-50年里，男性生殖健康的几个方面发生了更糟的变化。对壬基酚（p-NP）是一种具有雌激素特性的环境毒物，对其对男性生育能力的影响进行了测试。当成年雄性大鼠暴露于100 mg kg(-1) Q-NP时，精子小管的组织学参数受到不良影响。尽管在暴露开始时，这些男性的精子发生已经建立，但p-NP仍然对精管的组织学有影响。将剂量增加到250 mg kg（-1）还会导致体重增加较小和附睾毒性的迹象，而400 mg kg（-1）也会损害睾丸质量和精子数量。在最后两组中，一些动物的精子发生也受到影响。由于p-NP对大鼠体内已建立的精子发生有影响，人们可以推测，同样的影响也可能发生在人类身上。结果表明，p-NP对睾丸和附睾都有毒性作用，这两种结构都可能在损害男性生育能力方面起重要作用。即使p-NP浓度较低，暴露时间较长，生物积累也可能增强其负面影响。
Infertility is a sad reality and it is now evident that several aspects of male reproductive health have changed for the worse over the past 30-50 years. para-nonylphenol (p-NP), an environmental toxicant with oestrogenic properties, was tested for its effect on male fertility potential. When adult male rats were exposed to 100 mg kg(-1) Q-NP the histological parameters of the seminiferous tubules were adversely affected. Although spermatogenesis was already established in these males at the time exposure commenced, p-NP still had an effect on the histology of the seminiferous tubules. Increasing the level to 250 mg kg(-1) additionally resulted in a smaller weight gain and signs of epididymal toxicity, while 400 mg kg(-1) also impaired testicular mass and sperm count. In the last two groups spermatogenesis was also affected in some animals. Because p-NP had an effect on established spermatogenesis in the rat, one could speculate that the same effects might also occur in humans. It would appear that p-NP had toxic effects on both the testis and epididymis and both structures might be important in impairing male fertility. Bio-accumulation may enhance the negative effects at even lower p-NP concentrations over longer exposure periods than reported here.