Effect of body mass index on the performance characteristics of PSA-related markers to detect prostate cancer.
Effect of body mass index on the performance characteristics of PSA-related markers to detect prostate cancer.
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体重指数对 PSA 相关标志物检测前列腺癌性能特征的影响
DOI：
10.1038/srep19034
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发表时间：
2016-01-12
影响因子：
4.6
通讯作者：
Ye DW
中科院分区：
文献类型：
--
作者：
Zhu Y;Han CT;Zhang GM;Liu F;Ding Q;Xu JF;Vidal AC;Freedland SJ;Ng CF;Ye DW
检查前列腺特异性抗原（PSA）和PSA相关标志物对前列腺癌（PCa）的预测性能是否受体重指数（BMI）的影响。从三个三级中心招募接受多中心前列腺活检的PSA 2-10 ng/mL患者。测量的血清标志物包括总PSA（tPSA）、游离PSA/总PSA（f/tPSA）、p2PSA、p2PSA百分比（%p2PSA）和前列腺健康指数（PHI）。血清标志物与PCa风险之间的关联通过logistic回归进行评估。使用受试者工作曲线下面积（AUC）定量每种标志物的预测性能。在516名男性中，18.2%在活检时患有PCa。对于所有测试的标志物，其对PCa风险的预测值在肥胖患者中低于正常体重患者。我们发现BMI与tPSA（P = 0.0026）和p2PSA（P = 0.038）之间存在统计学显著的相互作用。在正常体重患者中，PHI的AUC为0.872，在肥胖患者中为0.745，无论BMI类别如何，均优于其他预测因子。总之，PHI检测PCa的预测性能最好，不受BMI的影响。
To examine whether the predictive performance of prostate-specific antigen (PSA) and PSA-related markers for prostate cancer (PCa) is modified by body mass index (BMI). Patients with a PSA 2–10 ng/mL who underwent multicore prostate biopsies were recruited from three tertiary centers. Serum markers measured included total PSA (tPSA), free-to-total PSA (f/tPSA), p2PSA, percentage of p2PSA (%p2PSA), and prostate health index (PHI). The association between serum markers and PCa risk was assessed by logistic regression. Predictive performance for each marker was quantified using the area under the receiver operator curves (AUC). Among 516 men, 18.2% had PCa at biopsy. For all tested markers, their predictive value on PCa risk was lower in obese patients compared to normal weight patients. We found statistically significant interactions between BMI and tPSA (P = 0.0026) and p2PSA (P = 0.038). PHI achieved an AUC of 0.872 in normal weight patients and 0.745 in obese patients, which outperformed the other predictors regardless of BMI category. In conclusion, PHI achieved the best predictive performance for detecting PCa and was not influenced by BMI.