Estrogen/androgen balance in health and disease.
Estrogen/androgen balance in health and disease.
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健康和疾病中的雌激素/雄激素平衡。
DOI：
10.1016/s0002-9378(79)80024-1
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发表时间：
1979
影响因子：
9.8
通讯作者：
G. Mikhail
中科院分区：
文献类型：
--
作者：
T. Motohashi;C. Wu;H. Abdel;N. Marymor;G. Mikhail
测定了5个正常月经周期每日血浆中游离睾酮（T）和雌二醇（E2）的百分比、T-E2结合球蛋白（TeBG）结合T和E2的百分比以及TeBG结合T的能力。这些结合参数在整个循环中趋于保持恒定。它们各自的平均值（±SE）分别为：2.61± 0.04%、54.5± 0.82%和22.2±0.69 ng/ml。在整个周期中，游离T、nqn-TeBG结合T（指数）和总T的每日血浆浓度趋于相互平行;它们在中期升高，在黄体期下降。每日E2/T比率的百分比'自由和百分比TeBG结合的分数保持恒定的整个周期，而每日E2/T比率的自由，指数，和总激素浓度显示出类似的模式，在月经周期中的每日E2水平。在高雄激素状态下，例如在多毛的女性或男性中，E2/T比率降低与（1）游离T和E2百分比增加，（2）TeBG结合T和E2百分比降低，和（3）TeBG的T结合能力降低有关。在高雌激素状态下，例如在孕妇中，升高的E2倾向于（1）降低游离T和E2的百分比，（2）增加TeBG结合的T和E2的百分比，以及（3）也急剧增加T结合。TeBG的能力。直到E2/T比值超出正常范围，才检测到E2和T结合参数的变化。
The percent free testosterone (T) and estradiol (E2, the percent T and E2 bound by T-E2-binding globulin (TeBG), and the T-binding capacity of TeBG in the daily plasma of five normal menstrual cycles were measured. These binding parameters tend to remain constant throughout the cycle. Their respective mean (±SE) values were: 2.61±0.04%, 54.5±0.82%, and 22.2±0.69 ng/ml. The daily plasma concentrations of the free, the nqn-TeBG-bound (index), and the total T tend to parallel each other throughout the cycle; they were elevated at the mldcycle and dec; reased during the luteal phase. The daily E2/T ratios of the percent'free and the percent TeBG-bound fractions remained constant throughout the cycle, while the daily E2/T ratios of the free, index, and total hormone concentration showed a pattern similar to that of the daily E2 level in the menstrual cycle. In a hyperandrogenic state, such as in hirsute women or men, the decreased E2/T ratio was associated with (1) increased percent free T and E2,(2) decreasec; l percent TeBG-bound T and E2, and (3) decreased T-binding capacity of TeBG. In a hyperestrogenic state, such as in pregnant women, the elevated E2 tends to (1) decrease the percent free T and E2,(2) increase the percent TeBG-bound T and E2, and (3) also drastically increase T-binding. capacity of TeBG. Changes in the binding parameters of E2 and T were not detected until the E2/T ratio fell outside the wide normal range.