Noble gas neuroprotection: xenon and argon protect against hypoxic-ischaemic injury in rat hippocampus in vitro via distinct mechanisms
Noble gas neuroprotection: xenon and argon protect against hypoxic-ischaemic injury in rat hippocampus in vitro via distinct mechanisms
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DOI：
10.1016/j.bja.2019.07.010
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发表时间：
2019-11-01
影响因子：
9.8
通讯作者：
Dickinson, Robert
中科院分区：
文献类型：
--
作者：
Koziakova, Mariia;Harris, Katie;Dickinson, Robert
背景：稀有气体可能为脑缺血和创伤性脑损伤等神经损伤提供新的治疗方法。很少有研究在相同的条件下在相同的模型中评估完整的惰性气体系列。方法：我们使用体外缺氧-缺血模型来评估惰性气体系列、氦、霓气、氩、氪和氙气的神经保护特性。结果：氙气和Ar都是有效的神经保护剂，其中0.5atm的氙气和0.5atm的Ar气可使损伤减轻96%(P
Background: Noble gases may provide novel treatments for neurological injuries such as ischaemic and traumatic brain injury. Few studies have evaluated the complete series of noble gases under identical conditions in the same model.Methods: We used an in vitro model of hypoxia-ischaemia to evaluate the neuroprotective properties of the series of noble gases, helium, neon, argon, krypton, and xenon. Organotypic hippocampal brain slices from mice were subjected to oxygen-glucose deprivation, and injury was quantified using propidium iodide fluorescence.Results: Both xenon and argon were equally effective neuroprotectants, with 0.5 atm of xenon or argon reducing injury by 96% (P