TRADITIONAL MEDICINAL-PLANTS OF THAILAND .20. CYTOTOXIC AND ANTIMALARIAL BISBENZYLISOQUINOLINE ALKALOIDS FROM STEPHANIA-ERECTA
TRADITIONAL MEDICINAL-PLANTS OF THAILAND .20. CYTOTOXIC AND ANTIMALARIAL BISBENZYLISOQUINOLINE ALKALOIDS FROM STEPHANIA-ERECTA
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DOI：
10.1021/np50091a005
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发表时间：
1993-01-01
影响因子：
5.1
通讯作者：
RUANGRUNGSI, N
中科院分区：
文献类型：
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作者：
LIKHITWITAYAWUID, K;ANGERHOFER, CK;RUANGRUNGSI, N
从千金藤（Stephania erecta）的块茎中分离得到一个新生物碱（+）-2-N-甲基特洛宾[1]和12个已知的双苄基异喹啉类化合物。通过广泛使用几种ID和2D NMR技术，获得了1的结构测定和完整的H-1-和明确的C-13-NMR归属。所有生物碱抑制恶性疟原虫株D-6和W-2的生长，并显示与培养的哺乳动物细胞的电池的非选择性细胞毒性。这些数据用于计算选择性指数。相对于已知的抗疟药，这些bisbelkzylisoquinoline生物碱目前似乎不是有希望的临床候选药物。
(+)-2-N-Methyltelobine [1], a new alkaloid, together with twelve known bisbenzylisoquinolines, was isolated from the tubers of Stephania erecta. The structure determination and the complete H-1- and unambiguous C-13-nmr assignments of 1 were obtained through extensive use of several ID and 2D nmr techniques. All alkaloids inhibited the growth of cultured Plasmodium falciparum strains D-6 and W-2 and displayed nonselective cytotoxicity with a battery of cultured mammalian cells. These data were used for the calculation of selectivity indices. Relative to known antimalarial agents, these bisbelkzylisoquinoline alkaloids do not appear to be promising clinical candidates at the present time.