Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development
Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development
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DOI：
10.1002/dvdy.21626
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发表时间：
2008-08-01
影响因子：
2.5
通讯作者：
Roskams, A. Jane
中科院分区：
文献类型：
--
作者：
MacDonald, Jessica L.;Roskams, A. Jane
组蛋白去乙酰化酶（HDAC）催化的组蛋白去乙酰化是一种常见的染色质表观遗传修饰，与基因沉默有关。虽然HDAC抑制剂在临床上用于治疗神经系统疾病，如癫痫，但对HDAC在中枢神经系统中的表达模式知之甚少。确定大脑中表达HDAC 1和HDAC 2的细胞类型和发育阶段对于确定HDAC抑制剂的治疗作用模式和评估潜在的副作用非常重要。在这里，我们研究了HDAC 1和HDAC 2在多个发育年龄的小鼠大脑中的表达。HDAC 1在神经干细胞/祖细胞和神经胶质中表达。相比之下，HDAC 2在神经祖细胞中启动，并在有丝分裂后的成神经细胞和神经元中上调，但在完全分化的神经胶质中不上调。这些结果确定了HDAC表达的关键发育阶段，并表明可能利用HDAC 1和/或HDAC 2的神经发育的转变。
The deacetylation of histone proteins, catalyzed by histone deacetylases (HDACs), is a common epigenetic modification of chromatin, associated with gene silencing. Although HDAC inhibitors are used clinically to treat nervous system disorders, such as epilepsy, very little is known about the expression pattern of the HDACs in the central nervous system. Identifying the cell types and developmental stages that express HDAC1 and HDAC2 within the brain is important for determining the therapeutic mode of action of HDAC inhibitors, and evaluating potential side effects. Here, we examined the expression of HDAC1 and HDAC2 in the murine brain at multiple developmental ages. HDAC1 is expressed in neural stem cells/progenitors and glia. In contrast, HDAC2 is initiated in neural progenitors and is up-regulated in post-mitotic neuroblasts and neurons, but not in fully differentiated glia. These results identify key developmental stages of HDAC expression and suggest transitions of neural development that may utilize HDAC1 and/or HDAC2.