Sleep duration, C-reactive protein and risk of incident coronary heart disease - results from the Framingham Offspring Study
Sleep duration, C-reactive protein and risk of incident coronary heart disease - results from the Framingham Offspring Study
复制标题
DOI：
10.1016/j.numecd.2013.12.012
复制
发表时间：
2014-06-01
影响因子：
3.9
通讯作者：
Kang, S.
中科院分区：
文献类型：
--
作者：
Liu, J.;Yuen, J.;Kang, S.
背景：睡眠时间和C-反应蛋白（CRP）都是冠心病（CHD）的有用预测因子。CRP水平升高与异常的睡眠时间有关。然而，目前还不清楚CRP是否影响CHD的风险预测的睡眠duration.Methods和结果：共3381人从Frachial Offspring研究，年龄30+，CHD免费，并没有错过测量CRP和睡眠持续时间，并遵循到2007年底被列入本分析。采用考克斯回归模型的风险比（HR）评估睡眠时间、CRP水平和冠心病发病风险之间的关联强度。校正年龄和性别后，与睡眠时间7-8 h（n = 2512）相比，睡眠时间= 9 h（n = 281）的CHD事件的HR（95% CL）分别为1.42（1.15，1.76，p < 0.005）。对其他协变量（包括CRP）的进一步调整并未改变CHD风险相关性。当受试者按睡眠时间（≥ 9 h）和CRP水平（≥ 3 mg/L）分为9组时，
Background: Both sleep-duration and C-reactive protein (CRP) are useful predictors of coronary heart disease (CHD). The increased CRP level is associated with the unusual sleep-duration. However, it is unclear whether CRP impacts the CHD risk prediction of sleep-duration.Methods and results: A total of 3381 individuals from the Framingham Offspring Study, aged 30+, CHD-free, and without missing measurement of CRP and sleep-duration and being followed to the end of 2007 were included in this analysis. Hazards ratio (HR) from the Cox regression models was used to evaluate the strength of association between the sleep-duration, CRP levels, and risk of incident CHD. Compared to sleep-duration 7-8 h (n = 2512) after adjusting for age and gender, the HR (95% CL) of incident CHD were 1.42 (1.15, 1.76, p < 0.005) for sleep-duration = 9 h (n = 281), respectively. A further adjustment for other covariates including CRP did not change the CHD risk association. When subjects were categorized into 9 groups by sleep-duration (= 9 h) and CRP levels (= 3 mg/L), and compared to those whose sleep-duration was 7-8 h and CRP levels were