The clinicopathological and prognostic features of Chinese and Japanese inpatients with lung cancer.
The clinicopathological and prognostic features of Chinese and Japanese inpatients with lung cancer.
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中国和日本住院肺癌患者的临床病理及预后特征
DOI：
10.18632/oncotarget.11850
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发表时间：
2016-10-11
期刊：
影响因子：
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通讯作者：
Zheng HC
中科院分区：
文献类型：
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作者：
Gao Y;Zhang JF;Li QC;Liu JJ;Liu LL;Yang XF;Jiang HM;Zheng HC
在此，我们回顾比较了中国医科大学附属第一医院(CMU 1，n=513)、深圳医院(CMU，n=1021)、肿瘤医院(CMUT，n=5378)、大连市第一附属医院(DMU，n=2251)和锦州医科大学(JMU，n=630)、日本高冈口世人医院(Takaoka Kouseiren Hospital，n=163)在肺癌临床病理行为和预后方面的差异。日本肺癌患者的肿瘤体积较小，TNM分期较低，鳞癌比例较低，小细胞癌和大细胞癌比例较高(p<；0.05)。生存分析表明，肿瘤大小是日本和中国癌症患者的预后因素(p<；0.05)。在DMU和CMU，女性患者和腺癌患者的比例高于其他医院(p<；0.05)，而CMUT和CMU 1的患者比其他医院年轻(p<；0.05)。CMUT、CMU1和JMU的鳞癌比例较高，而高冈和CMU1的大小细胞癌比例相同(p<；0.05)。CMUT的TNM分期高于JMU和Takaoka(p<；0.05)。女性肺癌患者发病年龄小、肿瘤体积大、腺癌比例高、TNM分期高(p<；0.05)。高冈地区年轻肺癌患者的肿瘤体积较小，腺癌比例较高，TNM分期较低(p<；0.05)。与日本肺癌患者相比，中国肺癌患者具有更多的攻击行为和更短的生存时间。应加强肺癌的预防，建立系统有效的筛查策略，特别是对年轻和女性患者进行筛查。
Here, we retrospectively compared the differences in clinicopathological behaviors and prognosis of lung cancer from the First Affiliated Hospital (CMU1, n=513), Shengjing Hospital (CMUS, n=1021), Tumor Hospital (CMUT, n=5378) of China Medical University, the First Affiliated Hospital of Dalian (DMU, n=2251) and Jinzhou (JMU, n=630) Medical University, Takaoka Kouseiren Hospital (Takaoka, n=163) of Japan. Japanese lung cancer patients showed smaller tumor size, lower TNM staging, lower ratio of squamous cell carcinoma and higher ratio of small and large cell carcinomas than Chinese patients (p<0.05). Survival analysis showed that tumor size was employed as a prognostic factor for the Japanese and Chinese cancer patients (p<0.05). In DMU and CMUS, the ratios of female patients or adenocarcinoma were higher than other hospitals (p<0.05), while the patients from CMUT and CMU1 were younger than the others (p<0.05). The ratios of squamous cell carcinoma from CMUT, CMU1 and JMU were higher than the others, while it was the same for the ratio of large and small cell carcinoma in Takaoka and CMU1 (p<0.05). TNM staging was higher in CMUT than JMU and Takaoka (p<0.05). The female patients of lung cancer showed young prone, large tumor size, a high ratio of adenocarcinoma and advanced TNM staging in comparison to the counterpart (p<0.05). The younger patients of lung cancer displayed smaller tumor size, higher ratio of adenocarcinoma, lower TNM staging than the elder in Takaoka (p<0.05). There were more aggressive behaviors and shorter survival time for Chinese than Japanese lung cancer patients. The prevention of lung cancer should be strengthened by establishing a systematic and effective screening strategy, especially for the young and female patients.