Ultrasound‐guided fine‐needle aspiration of a posterior neck dedifferentiated liposarcoma with MDM2 fluorescence in situ hybridization performed on a Pap‐stained smear
Ultrasound‐guided fine‐needle aspiration of a posterior neck dedifferentiated liposarcoma with MDM2 fluorescence in situ hybridization performed on a Pap‐stained smear
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超声引导下细针抽吸后颈去分化脂肪肉瘤，并在巴氏染色涂片上进行 MDM2 荧光原位杂交
DOI：
10.1002/dc.23200
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发表时间：
2015
影响因子：
1.3
通讯作者：
A. Rao
中科院分区：
文献类型：
--
作者：
R. Zreik;Krystal Soyalp;S. Ruiz;R. Ward;S. Dobin;Xiangbai Chen;Lina Liu;A. Rao
头颈部脂肪肉瘤虽然罕见，但往往是皮下和分化良好的。头颈部去分化脂肪肉瘤在文献中极为罕见。我们报告一位86岁男性后颈软组织发生去分化脂肪肉瘤的病例，并经细针抽吸诊断。抽吸涂片显示非典型脂肪瘤细胞和梭形细胞的双重群体。用荧光原位杂交(FISH)技术在Pap染色涂片上显示MDM2(鼠双分钟2)扩增。据我们所知，这是第一个在抽吸涂片上进行脂肪肉瘤的MDM2 FISH扩增的报告。诊断。细胞病变。2015年；43：320-324。©2014 Wiley期刊，Inc.
Head and neck liposarcomas, while rare, tend to be subcutaneous and well‐differentiated. Dedifferentiated liposarcomas of the head and neck are exceedingly rare in the literature. We present a case of a dedifferentiated liposarcoma arising in the soft tissue of the posterior neck of an 86‐year‐old man and diagnosed by fine‐needle aspiration. Aspirate smears showed a dual population of atypical lipomatous and spindled cells. MDM2 (murine double minute 2) amplification was demonstrated on a Pap‐stained smear using fluorescence in situ hybridization (FISH). To the best of our knowledge, this is the first report of MDM2 FISH amplification in a liposarcoma performed on an aspirate smear. Diagn. Cytopathol. 2015;43:320–324. © 2014 Wiley Periodicals, Inc.