Does rectal sparing ever occur in ulcerative colitis?
Does rectal sparing ever occur in ulcerative colitis?
复制标题
溃疡性结肠炎是否会保留直肠？
DOI：
10.1002/ibd.20592
复制
发表时间：
2008
影响因子：
4.9
通讯作者：
R. Odze
中科院分区：
文献类型：
--
作者：
J. Glickman;R. Odze
溃疡性结肠炎（UC）是一种以结肠弥漫性连续受累为特征的疾病，常累及直肠。直肠受累是UC的临床和病理学标志，并且假定在初始表现时累及所有患者，并且直肠通常是UC中结肠的最严重发炎区域。慢性结肠炎的组织学特征，如隐窝结构变形、基底淋巴浆细胞增多、潘氏细胞化生、基底淋巴聚集体和固有层弥漫性混合性炎症等，可能早在临床症状发作后1周就出现，通常在3-4周后就已确立。1 -3然而，在几种临床情况下，直肠可以部分或完全免于活动性或慢性炎症，这些情况概述如下。重要的是要熟悉这些情况，以避免误诊克罗恩病（CD）的基础上，发现直肠保留，可以避免。
I t is commonly believed that ulcerative colitis (UC) is characterized by diffuse continuous involvement of the colon, and always involves the rectum. Rectal involvement is a clinical and pathologic hallmark of UC, and is presumed to be involved in all patients at initial presentation, and the rectum is often the most severely inflamed region of the colon in UC. Histologic features of chronic colitis, such as crypt architectural distortion, basal lymphoplasmacytosis, Paneth cell metaplasia, basal lymphoid aggregates, and diffuse mixed inflammation in the lamina propria, among others, may be present as early as 1 week after the onset of clinical symptoms, and are usually well established after 3–4 weeks time.1–3 However, there are several clinical situations in which the rectum may be partially, or completely, spared of active or chronic inflammation, and these are outlined below. It is important to be familiar with these situations so that a misdiagnosis of Crohn’s disease (CD), based on the finding of rectal sparing, can be avoided.