Vasodilator effects of ibudilast on retinal blood vessels in anesthetized rats.
Vasodilator effects of ibudilast on retinal blood vessels in anesthetized rats.
复制标题
异丁司特对麻醉大鼠视网膜血管的血管扩张作用。
DOI：
10.1248/bpb.32.1924
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发表时间：
2009
影响因子：
2
通讯作者：
K. Ishii
中科院分区：
文献类型：
--
作者：
M. Noguchi;A. Mori;K. Sakamoto;T. Nakahara;K. Ishii
异丁司特(3-isobutyryl-2-isopropylpyrazolo[1，5-alpha]pyridine)在日本临床上被用作脑血管扩张剂。然而，异丁司特对视网膜血管的影响还没有得到充分的研究。因此，本研究的目的是观察异丁司特对大鼠视网膜血管的影响。雄性Wistar大鼠(8~10周龄)用硫代丁巴比妥(120 mg/kg)腹腔注射麻醉。用小动物眼底照相系统采集视网膜血管图像，测量视网膜血管直径。异丁司特(0.1和1 mg/kg，静脉注射)在不改变全身血压的情况下，视网膜血管直径和心率持续增加。非选择性环氧合酶抑制剂吲哚美辛(5 mg/kg，i.p)可显著降低异丁司特的作用。这些结果表明异丁司特在体内通过环氧合酶依赖的机制扩张视网膜血管。
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal blood vessels in rats in vivo. Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)). Retinal vascular images were captured with a fundus camera system for small animals, and the diameter of retinal blood vessels was measured. Ibudilast (0.1 and 1 mg/kg, intravenously (i.v.)) elicited a sustained increase in the diameter of retinal blood vessels and heart rate without altering systemic blood pressure. The effects of ibudilast were significantly reduced by treatment with the nonselective cyclooxygenase inhibitor indomethacin (5 mg/kg, i.p.). These results suggest that ibudilast dilates retinal blood vessels through cyclooxygenase-dependent mechanisms in rats in vivo.
影响因子：
4.8
作者：
Bing Sun;Haiquan Li;Y. Shakur;J. Hensley;S. Hockman;J. Kambayashi;V. Manganiello;Yongge Liu
通讯作者：
Bing Sun;Haiquan Li;Y. Shakur;J. Hensley;S. Hockman;J. Kambayashi;V. Manganiello;Yongge Liu