Spectrophotometric Methods for Simultaneous Estimation of Dexibuprofen and Paracetamol
Spectrophotometric Methods for Simultaneous Estimation of Dexibuprofen and Paracetamol
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同时测定右旋布洛芬和扑热息痛的分光光度法
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Amol A. Kulkarni
中科院分区：
文献类型：
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作者：
S. Chitlange;R. Soni;S. Wankhede;Amol A. Kulkarni
已开发出三种简单的分光光度法，用于同时测定片剂剂型中右布洛芬和扑热息痛的含量。使用乙醇(95%)作为溶剂。方法-I 涉及在 235.5 nm（等吸光点）和 249.5 nm（对乙酰氨基酚的最大值）处形成 Q 吸光度方程；方法 II 联立方程法涉及测量两个波长 223 nm（右布洛芬的最大值）和 249.5 nm（扑热息痛的最大值）的吸光度，方法 III 多组分分析模式涉及测量两个波长 223 nm（右布洛芬的最大值）和 249.5 nm（扑热息痛的最大值）的吸光度；对于所有三种方法，右布洛芬的线性范围为 2-7 µg/ml，扑热息痛的线性范围为 4-14 µg/ml。方法的准确度和精密度经过统计测定和验证。所有方法均表现出良好的重现性和回收率，% RSD 小于 1。所有方法均快速、专属、精密、准确，可成功应用于散装和组合剂型右布洛芬和扑热息痛的常规分析。
Three simple spectrophotometric methods have been developed for simultaneous estimation of dexibuprofen and paracetamol from tablet dosage form. Ethanol (95%) was used as solvent. Method-I involves, formation of Q-absorbance equation at 235.5 nm (isoabsorptive point) and 249.5 nm (�max of paracetamol); Method-II simultaneous equation method involves the measurement of absorbances at two wavelengths 223 nm (�max of dexibuprofen) and 249.5 nm (�max of paracetamol) and Method-III multicomponent mode of analysis involves the measurement of absorbances at two wavelengths 223 nm (�max of dexibuprofen) and 249.5 nm (�max of paracetamol); The linearity lies between 2-7 �g/ml for dexibuprofen and 4-14 �g/ml for paracetamol for all the three methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 1. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of dexibuprofen and paracetamol in bulk and combined dosage form.