Precision medicine in obstructive sleep apnoea
Precision medicine in obstructive sleep apnoea
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DOI：
10.1016/s2213-2600(19)30044-x
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发表时间：
2019-05-01
影响因子：
76.2
通讯作者：
Agusti, Alvar
中科院分区：
文献类型：
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作者：
Angel Martinez-Garcia, Miguel;Campos-Rodriguez, Francisco;Agusti, Alvar
阻塞性睡眠呼吸暂停 (OSA) 是一种异质且复杂的疾病；然而，诊断和管理仍然依赖于一套简单的工具和很少的治疗选择。精准医学已成为临床实践的下一个目标，其目标是提供个性化的治疗方案。针对各种呼吸系统疾病，在临床实践中实施精准医疗的方法已经出现，这种方法也可以很容易地导出到 OSA。在这里，我们提出了一个控制面板工具，从四个领域描述 OSA：疾病严重程度、生物活性、对患者的影响和病理生理特征。我们还提出了一种图形仪器，即临床指纹工具，可以随着时间的推移跟踪患者。这些工具可以解决 OSA 的复杂性，并根据个体患者的可治疗特征指导医生的行动方案，从而促进该疾病的精准医疗的临床实施。
Obstructive sleep apnoea (OSA) is a heterogeneous and complex disease; however, diagnosis and management still rely on a simple set of tools and few therapeutic options. Precision medicine has emerged as the next goal for clinical practice, with the objective being to offer individually tailored treatments. Ways of implementing precision medicine in clinical practice have emerged for various respiratory disorders, and such an approach could also be readily exported to OSA. Here, we propose a control panel tool that describes OSA in four domains: disease severity, biological activity, impact on the patient, and pathophysiological traits. We also propose a graphical instrument, the clinical fingerprint tool, to enable the tracking of patients over time. These tools can address the complexity of OSA and guide a physician's course of action on the basis of the treatable traits of an individual patient, thereby facilitating clinical implementation of precision medicine in the disorder.