Recovery of locomotion after injury in Drosophila melanogaster depends on proprioception
Recovery of locomotion after injury in Drosophila melanogaster depends on proprioception
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DOI：
10.1242/jeb.133652
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发表时间：
2016-06-01
影响因子：
2.8
通讯作者：
de Bivort, Benjamin
中科院分区：
文献类型：
--
作者：
Isakov, Alexander;Buchanan, Sean M.;de Bivort, Benjamin
运动是大多数动物生存所必需的。然而，介导运动的附肢的损伤是常见的。我们评估了腿截肢后果蝇行走的恢复。而截肢前的苍蝇平均以对称的方式探索开放的竞技场，前腿截肢诱导远离截肢侧的强烈转向偏差。然而，我们发现，无偏见的步行行为返回随着时间的推移，在野生型苍蝇，而恢复显着受损的本体感受突变体。为了确定这种运动障碍和恢复的生物力学基础，我们然后检查个人的腿部运动（步态）在一个精细的尺度。一个最小的数学模型，在步行过程中将神经动力学与身体力学联系起来，表明在右侧和左侧之间重新分配腿部力量能够实现观察到的恢复。总之，我们的研究表明，来自完整肢体的本体感受输入在与损伤后运动恢复相关的行为可塑性中起着至关重要的作用。
Locomotion is necessary for survival in most animal species. However, injuries to the appendages mediating locomotion are common. We assess the recovery of walking in Drosophila melanogaster following leg amputation. Whereas flies pre-amputation explore open arenas in a symmetric fashion on average, foreleg amputation induces a strong turning bias away from the side of the amputation. However, we find that unbiased walking behavior returns over time in wild-type flies, while recovery is significantly impaired in proprioceptive mutants. To identify the biomechanical basis of this locomotor impairment and recovery, we then examine individual leg motion (gait) at a fine scale. A minimal mathematical model that links neurodynamics to body mechanics during walking shows that redistributing leg forces between the right and left side enables the observed recovery. Altogether, our study suggests that proprioceptive input from the intact limbs plays a crucial role in the behavioral plasticity associated with locomotor recovery after injury.