A Diagnostic and Therapeutic Hydrogel to Promote Vascularization via Blood Sugar Reduction for Wound Healing
A Diagnostic and Therapeutic Hydrogel to Promote Vascularization via Blood Sugar Reduction for Wound Healing
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DOI：
10.1002/adfm.202213008
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发表时间：
2023-01-15
影响因子：
19
通讯作者：
Bai, Dingqun
中科院分区：
文献类型：
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作者：
Han, Xiaoyu;Chen, Shuyu;Bai, Dingqun
慢性高血糖损伤是破坏糖尿病伤口愈合的一个主要问题。将治疗与诊断结合起来，通过医学影像设备实时监测血糖浓度，适时进行精准干预，促进糖尿病伤口修复。本研究利用希夫碱反应构建了可注射的自修复透明质酸水凝胶，并将缩合反应合成的纳米酶（GOx-MnO2）与双重乳化法产生的血管内皮生长因子（VEGF）纳米气泡一起加载到水凝胶中，从而构建了创新的诊断和治疗水凝胶系统（US@GOx@VEGF水凝胶、UGV水凝胶）。该系统在实时监测葡萄糖浓度的同时，通过超声波以精确、无创的方式输送 VEGF，以消耗葡萄糖。 UGV水凝胶整合了诊断和治疗两个过程，通过超声波触发的爆炸有效释放VEGF。除此之外，这种新型创伤贴片能够通过磁共振成像监测0.5 m至7.8 x 10(-3) m范围内的Mn2+值和100 x 10(-3)至3 x 10(-3) m范围内的葡萄糖水平。综上所述，水凝胶实现了血糖水平的实时监测，通过无创干预维持血糖稳态，并快速促进糖尿病皮肤缺损的修复，为慢性伤口管理开辟了新途径。
Chronic hyperglycemic damage is a major problem that undermines diabetic wound healing. By combining treatment and diagnosis together, blood glucose concentration can be monitored real-time through medical imaging devices and precise interventions can be carried out at the right time to promote diabetic wound repair. In this study, an injectable self-healing hyaluronic acid hydrogel is constructed using Schiff base reaction, and nanoenzymes (GOx-MnO2) synthesized by condensation reaction, along with vascular endothelial growth factor (VEGF)-nanobubbles produced by double emulsification method, are loaded into the hydrogel, thus constructing an innovative diagnostic and therapeutic hydrogel system (US@GOx@VEGF hydrogel, UGV hydrogel). While monitoring glucose concentration in real-time, the system delivers VEGF through ultrasound in a precise and noninvasive way to deplete glucose. The UGV hydrogel integrates both processes of diagnosis and treatment, effectively releases VEGF through blasts triggered by ultrasound. Apart from this, this new trauma patch is capable of monitoring Mn2+ values ranging from 0.5 m to 7.8 x 10(-3) m and glucose levels from 100 x 10(-3) to 3 x 10(-3) m, through magnetic resonance imaging. In summary, the hydrogel realizes real-time monitoring of glucose level, maintains glucose homeostasis through noninvasive intervention, and rapidly promotes the repair of diabetic skin defects, opening up a new path for chronic wound management.