Serum LDL-C and LDL-C/HDL-C ratio are positively correlated to lymph node stages in males with colorectal cancer.
Serum LDL-C and LDL-C/HDL-C ratio are positively correlated to lymph node stages in males with colorectal cancer.
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发表时间：
2011-03
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通讯作者：
Ye-Liu Liu-Ye-Liu-Liu-2108335677;H. Qian;L. Qin;Xiao-jun Zhou;Bo Zhang
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作者：
Ye-Liu Liu-Ye-Liu-Liu-2108335677;H. Qian;L. Qin;Xiao-jun Zhou;Bo Zhang
背景/目的虽然在结直肠癌中已经报道了血脂水平的变化，但血脂水平与淋巴结分期之间的具体联系仍不确定。方法回顾性评价968例原发性结直肠癌根治性切除术患者的空腹血脂，包括TC、TG、HDL-C和LDL-C。为了确定营养状况，测定血清白蛋白水平并计算BMI。统计分析研究血脂与淋巴结分期的关系。结果血脂水平与淋巴结转移率密切相关，高LDL-C和低HDL-C倾向于淋巴结分期越晚。与N1期患者相比，N2期患者LDL-C/HDL-C比值升高具有统计学意义。多因素logistic回归分析显示，男性LDL-C水平和LDL-C/HDL-C比值与N2晚期有独立相关性，女性无独立相关性。此外，LDL-C/HDL-C比值可能是鉴别N2期比单独LDL-C水平更有效的生物标志物（OR值：2.85 vs. 1.63）。结论：血清LDL-C水平升高和LDL-C /HDL-C比值升高可能有利于淋巴结转移的发展，LDCC/HDL-C比值可能是鉴别晚期N2期的更有效的生物标志物，特别是对于男性结直肠癌患者。
BACKGROUND/AIMS Although changes in serum lipid profile have been reported in CRC, the specific association between serum lipid profile and lymph node stages remains uncertain. METHODOLOGY Fasting serum lipid profile, including TC, TG, HDL-C and LDL-C was retrospectively evaluated in 968 patients undergoing curative resection for primary CRC. To determine the nutritional status, the serum albumin levels were measured and BMI was calculated. Statistical analyses were performed to investigate the association of serum lipid profile with lymph node stages. RESULTS Serum lipid levels correlated well with rate of lymph node metastasis and high LDL-C and low HDL-C levels tended to present more advanced lymph node stages. The observed elevation of the LDL-C/HDL-C ratio for patients with N2 stage was statistically significant when compared with patients with N1 stage. When separated by gender, multivariate logistic regression analysis showed that both LDL-C levels and LDL-C/HDL-C ratio had independent association with advanced N2 stage in males, but not in females. In addition, LDL-C/HDL-C ratio might be a more effective biomarker for identifying N2 stage than LDL-C levels alone (OR value: 2.85 vs. 1.63). CONCLUSIONS Elevated serum LDL-C levels and an increased LDC-C/HDL-C ratio might favour development of lymph node metastasis and LDCC/HDL-C ratio might be a more effective biomarker for identifying advanced N2 stage than LDL-C levels alone, especially for male patients with CRC.