Facilitation of hippocampal potentials by suramin.
Facilitation of hippocampal potentials by suramin.
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苏拉明促进海马电位。
DOI：
10.1046/j.1471-4159.1995.64031097.x
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发表时间：
1995
影响因子：
4.7
通讯作者：
Wieraszko,A
中科院分区：
文献类型：
--
作者：
Wieraszko,A
评价了苏拉明（一种建议的嘌呤受体拮抗剂）对海马切片记录的诱发突触电位的影响。苏拉明诱导兴奋性突触后电位斜率和群体峰电位幅度（长时程增强，LTP）的非递减性、浓度依赖性放大。苏拉明的作用被腺苷酰亚氨二磷酸（ATP的不可水解类似物）完全消除，并被NMDA受体拮抗剂dl-2-氨基-5-膦酰基戊酸和MK-801显著降低。这些结果表明，除了作为P2受体的拮抗剂，苏拉明还能够以参与诱导LTP的机制的方式促进海马电位。
The influence of suramin, a suggested purino‐receptor antagonist, on the evoked synaptic potentials recorded from hippocampal slices was evaluated. The suramin induced a nondecremental, concentration‐dependent amplification of the slope of excitatory postsynaptic potential and magnitude of the population spike (long‐term potentiation, LTP). The effect of suramin was completely abolished by adenylimidodiphosphate, a nonhydrolyzable analogue of ATP, and markedly reduced by NMDA‐receptor antagonistsdl‐2‐amino‐5‐phosphonovaleric acid and MK‐801. These results indicate that, in addition to acting as an antagonist of P2receptors, suramin is also able to facilitate hippocampal potentials in a way that involves mechanisms participating in induction of LTP.