Screening adherence in BRCA1/2 families is associated with primary physicians' behavior
Screening adherence in BRCA1/2 families is associated with primary physicians' behavior
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DOI：
10.1002/ajmg.a.20431
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发表时间：
2004-02-15
影响因子：
2
通讯作者：
Lynch, HT
中科院分区：
文献类型：
--
作者：
Tinley, ST;Houfek, J;Lynch, HT
这项研究提供了一个长期的乳腺癌和卵巢癌筛查行为的评估，以及与BRCA 1/2突变或50%的女性坚持筛查相关的变量。该研究的参与者包括112名女性（33名突变携带者和79名风险为50%）。通过邮寄问卷收集数据，其中包括项目，以评估在过去2年的筛查行为，风险认知，癌症特异性困扰，坚持的决定因素，具体的障碍，和癌症史。统计分析包括描述性统计和非参数检验，以描述双变量关联和回归分析。每年乳房X线检查的依从率为72%，半年临床乳房检查（CBE）为21%，每月乳房自我检查（BSE）为29%，每年经阴道超声检查（US）为19%。只有一名参与者坚持半年一次的CA 125。与至少一种筛查方式有显著关联（P < 0.05）的变量包括：缺乏时间、婚姻状况、教育、癌症史、提供者关注、感知的筛查效用、克服障碍能力的信心、癌症特异性痛苦和风险感知。初级医生的行为，无论是在筛选建议或筛选性能的情况下，CBE，有显着的独立关联，坚持乳房X光检查，CBE，和美国的筛选建议。这项研究的结果突出了初级医生在支持他们的非常高风险的患者的依从性中发挥的重要作用。(C)威利-利斯公司
This study provides an assessment of longterm breast and ovarian cancer screening behaviors and the variables associated with adherence with screening among women with or at 50% for having a BRCA1/2 mutation. Participants in the study included 112 women (33 mutation carriers and 79 at 50% risk). Data was collected through a mailed questionnaire, which included items to assess screening behaviors in the last 2 years, risk perception, cancer specific distress, adherence determinants, specific barriers, and cancer history. Statistical analysis included descriptive statistics and non-parametric tests to describe bivariate associations and regression analysis. Adherence rates were 72% for annual mammography, 21% for semi-annual clinical breast exam (CBE), 29% for monthly breast self-exam (BSE), and 19% for annual transvaginal ultrasound (US). Only one participant was adherent with semi-annual CA125. Variables that had a significant association (P < 0.05) with at least one screening modality included: a lack of time, marital status, education, cancer history, provider concern, perceived screening utility, confidence in ability to overcome barriers, cancer specific distress, and risk perception. Primary physician behavior, either in terms of screening recommendations or screening performance in the case of CBE, had significant independent association with adherence to mammography, CBE, and US screening recommendations. The results of this study highlight the essential role that primary physicians play in supporting their very high-risk patients' adherence. (C) Wiley-Liss Inc.