Plasma glutathione peroxidase reduces phosphatidylcholine hydroperoxide.
Plasma glutathione peroxidase reduces phosphatidylcholine hydroperoxide.
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血浆谷胱甘肽过氧化物酶还原氢过氧化磷脂酰胆碱。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
S. Yoshimura
中科院分区：
文献类型：
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作者：
Y. Yamamoto;Y. Nagata;E. Niki;K. Watanabe;S. Yoshimura
研究了大鼠血浆谷胱甘肽过氧化物酶对磷脂酰胆碱氢过氧化物（PC-OOH）和胆固醇酯氢过氧化物（CE-OOH）的还原活性。PC-OOH被酶还原，CE-OOH不被酶还原。当所有硫醇被消耗时，酶对PC-OOH的还原停止，但添加谷胱甘肽后活性恢复，这表明谷胱甘肽对保持酶的还原形式很重要。这些结果与人类和大鼠血浆中存在CE-OOH而PC-OOH检测不到的发现一致，表明该酶的生理作用之一是减少PC-OOH。
The reducing activity of rat plasma glutathione peroxidase on phosphatidylcholine hydroperoxide (PC-OOH) and cholesteryl ester hydroperoxide (CE-OOH) was examined since these hydroperoxides are the major oxidation products of plasma. PC-OOH was reduced by the enzyme while CE-OOH was not. The reduction of PC-OOH by the enzyme ceased when all thiol was consumed, but the activity was recovered by the addition of glutathione, suggesting glutathione is important to keep the enzyme in the reduced form. These results are consistent with the findings that CE-OOH is present in human and rat plasmas while PC-OOH is undetectable and suggest that one of the physiological roles of the enzyme is to reduce PC-OOH.