The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
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DOI：
10.1523/jneurosci.2680-04.2004
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发表时间：
2004-11-10
影响因子：
5.3
通讯作者：
Weinberger, DR
中科院分区：
文献类型：
--
作者：
Pezawas, L;Verchinski, BA;Weinberger, DR
BDNF基因（val66met）的变异影响BDNF在神经元中的功能，预测人类记忆的变化，并与几种神经和精神疾病相关。在这里，我们表明，在磁共振成像扫描的大样本的正常的这种多态性影响海马和前额叶皮层的解剖，确定在大脑形态学与学习和记忆的遗传机制。
A variation in the BDNF gene ( val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of in brain morphology related to learning and memory.