Viewing Legionella pneumophila Pathogenesis through an Immunological Lens.
Viewing Legionella pneumophila Pathogenesis through an Immunological Lens.
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DOI：
10.1016/j.jmb.2019.07.028
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发表时间：
2019-10-04
影响因子：
5.6
通讯作者：
Shin, Sunny
中科院分区：
文献类型：
--
作者：
Liu, Xin;Shin, Sunny
嗜肺军团菌是严重肺炎军团菌病的病原体。L.嗜肺菌普遍存在于淡水环境中，在那里它在自由生活的原生动物中复制。受污染水源的雾化作用使细菌被吸入人的肺中。嗜肺菌可被肺泡巨噬细胞吞噬并在细胞内复制。Dot/Icm IV型分泌系统（T4 SS）是细胞内细菌复制和随后疾病所需的关键毒力因子之一。Dot/Icm装置将超过300种效应蛋白易位到宿主细胞胞质溶胶中。这些效应子干扰多种细胞过程，从而使细菌能够逃避吞噬体-溶酶体融合，并建立内质网衍生的含军团菌的空泡，这有利于细菌复制。反过来，免疫系统已经进化出许多策略来识别细胞内细菌，如L。嗜肺菌，导致有效的炎症反应，有助于消除感染。本文对L.在宿主免疫应答的背景下，嗜肺菌的发病机制。
Legionella pneumophila is the causative agent of the severe pneumonia Legionnaires’ disease. L. pneumophila is ubiquitously found in freshwater environments, where it replicates within free-living protozoa. Aerosolization of contaminated water supplies allows the bacteria to be inhaled into the human lung, where L. pneumophila can be phagocytosed by alveolar macrophages and replicate intracellularly. The Dot/Icm type IV secretion system (T4SS) is one of the key virulence factors required for intracellular bacterial replication and subsequent disease. The Dot/Icm apparatus translocates more than 300 effector proteins into the host cell cytosol. These effectors interfere with a variety of cellular processes, thus enabling the bacterium to evade phagosome–lysosome fusion and establish an endoplasmic reticulum-derived Legionella-containing vacuole, which facilitates bacterial replication. In turn, the immune system has evolved numerous strategies to recognize intracellular bacteria such as L. pneumophila, leading to potent inflammatory responses that aid in eliminating infection. This review aims to provide an overview of L. pneumophila pathogenesis in the context of the host immune response.
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影响因子：
5.4
作者：
Berrington, William R.;Iyer, Ravi;Wells, Richard D.;Smith, Kelly D.;Skerrett, Shawn J.;Hawn, Thomas R.
通讯作者：
Hawn, Thomas R.
影响因子：
3.1
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通讯作者：
Saito, A
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3.4
作者：
Archer KA;Alexopoulou L;Flavell RA;Roy CR
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6.7
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通讯作者：
Isberg RR
影响因子：
2.5
作者：
BECKERS, MC;YOSHIDA, S;GROS, P
通讯作者：
GROS, P