Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia.
Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia.
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患有持续性艾滋病毒抗原血症的男同性恋者患艾滋病相关综合症和艾滋病的风险。
DOI：
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发表时间：
1987
影响因子：
--
通讯作者：
J. van der Noordaa
中科院分区：
文献类型：
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作者：
F. de Wolf;J. Goudsmit;D. Paul;J M Lange;C. Hooijkaas;P. Schellekens;R. Coutinho;J. van der Noordaa
对198例人类免疫缺陷病毒（HIV）抗体血清阳性和58例HIV抗体血清转化者进行了平均19.3 （SEM 0.5）个月的研究，以评估HIV抗原血症与获得性免疫缺陷综合征（AIDS）及艾滋病相关复合物发生风险的关系。198例HIV抗体血清阳性男性中，40例（20.2%）在入境时抗原阳性，随访期间抗原阳性。58名HIV抗体血清转换者中有8人（13.8%），其余158名HIV抗体血清阳性男性中有20人（12.7%）在随访期间转为抗原阳性，导致HIV抗原血症的终点攻击率为14.3%。在HIV抗原阴性的男性中有25人（15.8%）被诊断为艾滋病相关复合物，在HIV抗原阳性的男性中有14人（20.7%）被诊断为艾滋病相关复合物。15名男性被诊断出患有艾滋病，导致HIV抗原阳性组的艾滋病终点发作率为23.9%，抗原阴性组为1.3%。无症状但持续存在艾滋病毒抗原血症的艾滋病毒抗体血清阳性男性患艾滋病和艾滋病相关并发症的风险增加。
One hundred and ninety eight men seropositive for human immunodeficiency virus (HIV) antibody and 58 HIV antibody seroconverters were studied for an average of 19.3 (SEM 0.5) months to assess the relation between HIV antigenaemia and the risk of developing the acquired immune deficiency syndrome (AIDS) and AIDS related complex. Forty (20.2%) of the 198 HIV antibody seropositive men were antigen positive at entry and remained so during follow up. Eight (13.8%) of the 58 HIV antibody seroconverters and 20 (12.7%) of the remaining 158 HIV antibody seropositive men became antigen positive during follow up, resulting in an end point attack rate for HIV antigenaemia of 14.3%. AIDS related complex was diagnosed in 25 (15.8%) of the HIV antigen negative men and in 14 (20.7%) of the HIV antigen positive men. AIDS was diagnosed in 15 men, resulting in an end point attack rate for AIDS of 23.9% in the HIV antigen positive group and 1.3% in the antigen negative group. HIV antibody seropositive men without symptoms but with persistent HIV antigenaemia are at increased risk of developing AIDS and AIDS related complex.
从感染人类免疫缺陷病毒（HIV）到艾滋病发病的时间。
DOI：
10.1093/infdis/154.4.694
发表时间：
1986
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Taylor,JM;Schwartz,K;Detels,R
通讯作者：
Detels,R