Circ-E-Cad encodes a protein that promotes the proliferation and migration of gastric cancer via the TGF-β/Smad/C-E-Cad/PI3K/AKT pathway.
Circ-E-Cad encodes a protein that promotes the proliferation and migration of gastric cancer via the TGF-β/Smad/C-E-Cad/PI3K/AKT pathway.
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Circ-E-Cad 编码一种通过 TGF-β/Smad/C-E-Cad/PI3K/AKT 通路促进胃癌增殖和迁移的蛋白质
DOI：
10.1002/mc.23491
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发表时间：
2023-03
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
Accumulating studies indicate that circular RNAs (circRNAs) play critical roles in cancer progression. Most of them have been reported to act as microRNA sponges or interact with RNA‐binding proteins; however, their full range of functions remains largely unclear. Recently, an increasing number of circRNAs have been found to encode proteins. C‐E‐Cad, a protein encoded by circular E‐cadherin (circ‐E‐Cad), has been shown to have a great influence in the progression of glioblastoma, but its specific role in gastric cancer (GC) is unclear. Here, we found that both circ‐E‐Cad and C‐E‐Cad were upregulated in GC cell lines and GC tissues compared with a human gastric epithelial cell line (GES‐1) and normal tissues. Knockdown of circ‐E‐Cad suppressed GC cell line proliferation and metastasis in vitro and in vivo, whereas overexpression of C‐E‐Cad had the opposite effects. Immunoblotting revealed that C‐E‐Cad exerted tumor‐promoting functions by regulating the PI3K/AKT pathway. A rescue experiment showed that C‐E‐Cad but not circ‐E‐Cad was the executor of protumor biological functions. In addition, we demonstrated that the C‐E‐Cad expression level could have been increased by the TGF‐β/Smad pathway. In summary, our results indicated that the TGF‐β/Smad pathway could increase the expression of C‐E‐Cad to regulate GC cell proliferation, migration, and epithelial‐mesenchymal transition by affecting PI3K/AKT signaling.
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FBXW7 环状 RNA 在抑制神经胶质瘤肿瘤发生中的新作用。
DOI：
10.1093/jnci/djx166
发表时间：
2018-03-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Yang Y;Gao X;Zhang M;Yan S;Sun C;Xiao F;Huang N;Yang X;Zhao K;Zhou H;Huang S;Xie B;Zhang N
通讯作者：
Zhang N
影响因子：
28.5
作者：
Liu J;Pan C;Guo L;Wu M;Guo J;Peng S;Wu Q;Zuo Q
通讯作者：
Zuo Q
影响因子：
3.7
作者：
Salzman J;Gawad C;Wang PL;Lacayo N;Brown PO
通讯作者：
Brown PO
影响因子：
4.5
作者：
Salzman J;Chen RE;Olsen MN;Wang PL;Brown PO
通讯作者：
Brown PO
环状 RNA 编码的致癌 E-钙粘蛋白变体通过激活 EGFR-STAT3 信号传导促进胶质母细胞瘤致瘤性。
影响因子：
21.3
作者：
Gao, Xinya;Xia, Xin;Zhang, Nu
通讯作者：
Zhang, Nu