Insight into Crohn’s disease pathomorphology
Insight into Crohn’s disease pathomorphology
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深入了解克罗恩病病理形态学
DOI：
10.1007/s00261-012-9885-3
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发表时间：
2012
影响因子：
--
通讯作者：
Neurath MF
中科院分区：
文献类型：
--
作者：
Mudter J;Neurath MF
克罗恩病（CD）与溃疡性结肠炎一起属于炎症性肠病（IBD）的两种主要形式。尽管其病因尚不清楚，但已证明几种遗传和免疫因素和细胞（特别是T细胞）参与了IBD的发病机制。在这些因素中，促炎T细胞及其分泌的细胞因子似乎是诱导和延续肠道炎症的主要效应因子。除了局部炎症作用外，T细胞和炎症复合物迁移并诱导肠外表现和并发症的机制也非常明确。本文综述了目前对乳糜泻粘膜炎症病理形态学的研究，重点介绍了t细胞归巢、肠外表现和纤维化的免疫机制。
Crohn’s disease (CD) belongs together with ulcerative colitis to the two major forms of inflammatory bowel diseases (IBD). Although its etiology remains poorly understood, several genetic and immune factors and cells (especially T cells) have been shown to be involved in the pathogenesis of IBD. Among these factors, proinflammatory T cells and their secreted cytokines seem to be the main effectors in induction and perpetuation of the intestinal inflammation. Beside the local inflammatory effect, there is a very clear defined mechanism where T cells and inflammatory complexes migrate and induce extraintestinal manifestation and complications. This article reviews current knowledge of the pathomorphology of mucosal inflammation in CD focusing especially on the immune mechanisms of T-cell homing, extraintestinal manifestations and fibrogenesis.