A Novel Approach to Evaluate Brain Activation for Lower Extremity Motor Control
A Novel Approach to Evaluate Brain Activation for Lower Extremity Motor Control
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DOI：
10.1111/jon.12645
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发表时间：
2019-09-01
影响因子：
2.4
通讯作者：
Myer, Gregory D.
中科院分区：
文献类型：
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作者：
Grooms, Dustin R.;Diekfuss, Jed A.;Myer, Gregory D.
背景和目的本研究的目的是评估新型 MR 安全下肢运动控制神经成像范例的一致性，以引发可靠的感觉运动区域大脑活动。方法 参与者仰卧在 3T MRI 扫描仪中，以 1.2 Hz 的速度完成多组单侧腿部推举，结合踝关节、膝关节和髋关节的伸展和屈曲运动以对抗阻力。感兴趣区（ROI）由主要涉及下肢运动控制的区域（左右初级运动皮层、初级体感皮层、前运动皮层、次级体感皮层、基底神经节和小脑）组成。结果基于混合效应配对样本 t 检验的分组分析显示，会话之间的大脑活动没有差异 (P > .05)。感觉运动区域的组内相关系数在平均信号变化百分比（0.621 至 0.918）和 Z 分数（0.697 至 0.883）方面从良好到优秀，但左侧次级体感皮层信号变化百分比 (0.165) 除外。结论 这些结果表明，模拟蹲下、迈步和跳跃落地的运动范围的负重下肢力量产生和衰减任务对于纵向神经影像应用来说是可靠的，并支持在进一步研究中使用该范例来检查治疗干预和动态下肢运动功能的变化。
BACKGROUND AND PURPOSE The purpose of this study was to assess the consistency of a novel MR safe lower extremity motor control neuroimaging paradigm to elicit reliable sensorimotor region brain activity. METHODS Participants completed multiple sets of unilateral leg presses combining ankle, knee, and hip extension and flexion movements against resistance at a pace of 1.2 Hz while lying supine in a 3T MRI scanner. Regions of Interest (ROI) consisted of regions primarily involved in lower extremity motor control (right and left primary motor cortex, primary somatosensory cortex, premotor cortex, secondary somatosensory cortex, basal ganglia, and the cerebellum). RESULTS The group analysis based on mixed effects paired samples t-test revealed no differences for brain activity between sessions (P > .05). Intraclass correlation coefficients in the sensorimotor regions were good to excellent for average percent signal change (.621 to .918) and Z-score (.697 to .883), with the exception of the left secondary somatosensory cortex percent signal change (.165). CONCLUSIONS These results indicate that a loaded lower extremity force production and attenuation task that simulates the range of motion of squatting, stepping, and landing from a jump is reliable for longitudinal neuroimaging applications and support the use of this paradigm in further studies examining therapeutic interventions and changes in dynamic lower extremity motor function.