Cortical intercorrelations of frontal area volumes in schizophrenia
Cortical intercorrelations of frontal area volumes in schizophrenia
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DOI：
10.1016/j.neuroimage.2005.05.024
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发表时间：
2005-10-01
期刊：
影响因子：
5.7
通讯作者：
Shihabuddin, L
中科院分区：
文献类型：
--
作者：
Mitelman, SA;Buchsbaum, MS;Shihabuddin, L
背景：一些MRI研究报道了精神分裂症患者选定皮质区域之间的异常区域体积相关性。方法：对正常人(n=42)和精神分裂症患者(n=106)额叶灰质和白质体积与皮质Brodmann‘s面积的相关性进行了详细的分析，将其分为预后良好(n=52)和预后不良(Kraepelian；It=54)亚型。结果：精神分裂症患者额叶灰质体积与颞叶体积相关，而在正常受试者中不相关。一些额叶-顶叶和额叶-枕叶的相关关系也显示出类似的模式。与正常人相比，精神分裂症患者额叶内的相互关系较弱或缺乏，特别是左侧运动前运动区和眼动区(4，6，8)和背外侧区44之间，以及左侧9区和46区与24区(扣带回)之间的相关性。与正常人或预后好的患者相比，精神分裂症患者左额叶9区与内侧和外侧颞叶皮质的相关性较弱。结论：精神分裂症患者额叶和更多的后部皮质之间存在与任务或症状相关的功能障碍的结构成分，优先受累于额颞叶，而额顶顶叶和额枕系统受累较少。额叶内左侧运动前运动区和布罗卡区之间的区域联系受损可能在精神分裂症的语言处理缺陷中发挥作用，而额扣带连接中断可能导致工作记忆障碍。较差的预后可能与左半球前额叶与扣带回和颞区之间更广泛的连接中断有关，这与左侧扣带或钩状束的路线中断一致。(C)2005 Elsevier Inc.保留所有权利。
Background: Abnormal regional volume intercorrelations between selected cortical areas in schizophrenia patients were previously reported in several MRI studies.Methods: A detailed analysis of frontal gray and white matter volume correlations with Brodmann's area volumes in the rest of the cortex was undertaken in normal subjects (n = 42) and patients with schizophrenia (n = 106), divided into good-outcome (n = 52) and poor-outcome (Kraepelinian; it = 54) subtypes.Results: Frontal gray matter volumes were correlated with temporal lobe volumes in schizophrenics but not in normal subjects. Some frontal - parietal and frontal-occipital correlations showed a similar pattern. In comparison to normal subjects, schizophrenia patients showed weaker or absent intercorrelations intrafrontally, specifically between left motor-premotor and eye-movement areas (4, 6, 8) and dorsolateral area 44, as well as between left areas 9 and 46 vs. area 24 (cingulate gyrus). Poor outcome among patients with schizophrenia was associated with weaker correlations between left frontal area 9 and both medial and lateral temporal cortices, as compared to normal subjects or good-outcome patients.Conclusions: There appears to be a structural component in the task or symptom-related dysfunctional interactions between the frontal and more posterior cortical regions with preferential pathological involvement of frontotemporal and more limited involvement of frontoparietal and fronto-occipital systems in schizophrenia. Impaired regional associations within the frontal lobe, between left motor-premotor and Broca's areas, may play a role in language processing deficits in schizophrenia, while frontocingulate disconnection may result in working memory disturbances. Poor outcome may be associated with more widespread disconnections between prefrontal vs. cingulate and temporal regions in the left hemisphere, consistent with a disruption along the course of the left cingulum or uncinate bundles. (C) 2005 Elsevier Inc. All rights reserved.