PHARMACOGENETICS OF METHYLATION - RELATIONSHIP TO DRUG-METABOLISM
PHARMACOGENETICS OF METHYLATION - RELATIONSHIP TO DRUG-METABOLISM
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DOI：
10.1016/s0009-9120(88)80002-x
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发表时间：
1988-08-01
影响因子：
2.8
通讯作者：
WEINSHILBOUM, R
中科院分区：
文献类型：
--
作者：
WEINSHILBOUM, R
药物遗传学是研究药物反应的遗传变异的学科。药物代谢的遗传差异是药物反应或药物不良反应遗传变异的最常见原因。甲基共轭是许多药物生物转化的重要途径。在过去的十年中进行的实验表明，在人体组织中，催化S-甲基化、O-甲基化和N-甲基化的酶的活性的个体差异受遗传控制。这些遗传变异导致了甲基偶联药物在代谢、效应和毒性方面的个体差异。用于研究甲基化的药物遗传学的方法也可适用于研究药物代谢的其他途径中的遗传变异。
Pharmacogenetics is the study of inherited variation in drug response. Genetic differences in drug metabolism are the most common causes for inherited variations in drug response or adverse reactions to medications. Methyl conjugation is an important pathway in the biotransformation of many drugs. Experiments performed during the past decade showed that individual variations in the activities of enzymes that catalyzeS-methylation,O-methylation andN-methylation are under genetic control in human tissue. These inherited variations are responsible for individual differences in metabolism, effect, and toxicity of drugs that undergo methyl conjugation. The approach used to study the pharmacogenetics of methylation may also be applicable to the study of inherited variations in other pathways of drug metabolism.