Helium charged‐particle radiotherapy of locally advanced carcinoma of the esophagus, stomach, and biliary tract*
Helium charged‐particle radiotherapy of locally advanced carcinoma of the esophagus, stomach, and biliary tract*
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氦带电粒子放射治疗局部晚期食管癌、胃癌和胆道癌*
DOI：
10.1097/00000421-198312000-00004
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Austin
中科院分区：
文献类型：
--
作者：
J. Castro;George T. Y. Chen;S. Pitluck;Aude Cartigny;T. Phillips;W. M. Saunders;M. Collier;K. Woodruff;M. Friedman;M. Austin
&NA;65例食管鳞状细胞癌（32例患者）、胃癌（18例患者）和胆道癌（15例患者）患者接受了6000 - 7000当量rad（60 - 70格雷当量）的氦放射治疗，每次2.0 GyE，每天4次，使用多射野，分散布拉格峰治疗。所有患者均为局部晚期疾病，无远处转移证据。完成了组织不均匀性的部分补偿。虽然症状缓解和肿瘤消退是常见的，但大多数患者（77%）发生局部失败。中位生存期为8个月。相对于正常组织，似乎不能实现肿瘤剂量的增加，该增加足以使局部控制率高于低LET照射的历史控制率。将使用更重的粒子（如氖或硅）进行进一步研究，希望对这些难以控制的肿瘤产生更大的生物学效应。
&NA; Sixty‐five patients with squamous carcinoma of the esophagus (32 patients), carcinoma of the stomach (18 patients) and carcinoma of the biliary tract (15 patients) received from 6000 to 7000 equivalent rad (60‐70 Gray‐equivalents) of helium radiotherapy at 2.0 GyE per fraction, four fractions per day, using multiportal, spread‐out Bragg peak therapy. All patients had locally advanced disease without evidence of distant metastases. Partial compensation for tissue inhomogeneities was accomplished. Although palliation of symptoms and regression of tumor was commonly seen, local failure occurred in most patients (77%). The median survival was 8 months. It does not appear that an increase in tumor dose relative to normal tissues can be achieved that would be high enough to increase locoregional control rates over historical control rates with low‐LET irradiation. Further studies will be carried out with heavier particles such as neon or silicon in hopes of achieving greater biological effect on these difficult‐to‐control tumors.